Near-Infrared-Light-Responsive Lipid Nanoparticles as an Intelligent Drug Release System for Cancer Therapy
Near-Infrared-Light-Responsive Lipid Nanoparticles as an Intelligent Drug Release System for Cancer Therapy
复制标题
近红外光响应脂质纳米颗粒作为癌症治疗的智能药物释放系统
DOI：
10.1021/acs.chemmater.9b00150
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发表时间：
2019-06-11
影响因子：
8.6
通讯作者：
Chen, Haiyan
中科院分区：
文献类型：
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作者：
Wang, Fei;Yuan, Zhenwei;Chen, Haiyan
常规化疗药物由于与健康组织的非特异性相互作用而引起全身性副作用，这显著阻碍了它们的耐受性和功效。在此，我们开发了一种智能药物递送系统，其中药物释放可以由肿瘤部位的近红外（NIR）光触发，从而防止对正常组织的损伤。这种光响应系统是基于由月桂酸和硬脂酸的低共熔混合物组成的脂质纳米颗粒建立的，其熔点为39摄氏度。抗癌药物阿霉素和近红外吸收染料亚甲基双丙烯酰胺共封装到这些纳米颗粒中，而cRGD和CD47肽缀合在其表面上用于肿瘤靶向和免疫逃避。所得纳米粒具有响应于近红外辐射的快速药物释放、突出的光热效应和良好的癌症靶向能力。此外，在多种肿瘤模型中的体内研究都表明，纳米颗粒可以特异性地在肿瘤部位积聚，并大大减小肿瘤大小，而不会产生全身副作用，这表明这种智能药物递送系统在未来癌症治疗中具有很大的潜力。
Conventional chemotherapeutic drugs cause systemic side effects due to nonspecific interactions with healthy tissues, which significantly hinders their tolerability and efficacy. Herein, we developed an intelligent drug delivery system, in which the drug release can be triggered by near infrared (NIR) light at the tumor locus, prohibiting damage to normal tissues. This light-responsive system was established based on lipid nanoparticles consisting of a eutectic mixture of lauric acid and stearic acid, which have a melting point at 39 degrees C. Anticancer drug doxorubicin and NIR-absorbing dye methylenebisacrylamide were coencapsulated into these nanoparticles, while cRGD and CD47 peptide were conjugated on their surfaces for tumor targeting and immune evasion. The resultant nanoparticles exhibited quick drug release in response to NIR irradiation, prominent photothermal effects, and good cancer targeting ability. Furthermore, in vivo studies in multiple tumor models all showed that the nanoparticles could specifically accumulate at the tumor site and drastically reduce tumor size without systemic side effects, demonstrating the promising potential of this intelligent drug delivery system for future cancer treatment.