Age-related changes in thrombopoietin in children: reference interval for serum thrombopoietin levels
Age-related changes in thrombopoietin in children: reference interval for serum thrombopoietin levels
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DOI：
10.1046/j.1365-2141.1999.01641.x
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发表时间：
1999-09-01
影响因子：
6.5
通讯作者：
Shimbo, T
中科院分区：
文献类型：
--
作者：
Ishiguro, A;Nakahata, T;Shimbo, T
我们使用灵敏的ELISA检测了254份无病儿童和成人志愿者血清样本的血小板生成素（TPO， Mpl配体）值。在所有样品中均检测到TPO，其值范围为0.25 ~ 9.18 fmol/ml。将受试者分为11个年龄组进行分析，TPO水平从出生到1月龄的平均值升高（3.73 ~ 5.92 fmol/ml），出生后第2天达到最高值，随后逐渐下降到成人水平（0.83 fmol/ml）。TPO值与血小板计数之间的关系在所有受试者中（r = 0.27）或仅在儿童中（r = 0.12）均不显著。在bb ~ 1月龄的儿童中，血清TPO值的95%参考区间为0.58 ~ 3.27 fmol/ml。血清TPO值与血浆TPO值有显著相关性：血清TPO值= -0.257 + 4.039 x血浆TPO值（r = 0.951, P < 0.001, n = 22）。这项研究首次报道了儿童发育过程中血液TPO水平的年龄依赖性变化。1月龄前血清TPO值显著升高，且与血浆TPO水平相关。
We studied thrombopoietin (TPO, Mpl ligand) values using a sensitive ELISA in 254 serum samples obtained from disease-free children and adult volunteers. TPO was detected in all samples, and its values ranged widely from 0.25 to 9.18 fmol/ml. When analysed by dividing the subjects into 11 age groups, the mean TPO levels from birth to 1 month of age were increased (3.73-5.92 fmol/ml), The highest values were found 2 d after birth: TPO levels then gradually decreased to adult levels (0.83 fmol/ml). The relationship between TPO values and platelet counts was not significant in all subjects (r = 0.27) or in children alone (r = 0.12). in children >1 month of age a 95% reference interval for serum TPO values was determined from 0.58 to 3.27 fmol/ml. A significant correlation was found between TPO values in serum and plasma: serum TPO values = -0.257 + 4.039 x plasma TPO values (r = 0.951, P < 0.001, n = 22). This study is the first to report age dependent changes in blood TPO levels throughout child development. Serum TPO values were significantly high up to 1 month of age and were correlated with plasma TPO levels.