Placental heme receptor LRP1 correlates with the heme exporter FLVCR1 and neonatal iron status.
Placental heme receptor LRP1 correlates with the heme exporter FLVCR1 and neonatal iron status.
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DOI：
10.1530/rep-14-0053
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发表时间：
2014-09
期刊：
影响因子：
--
通讯作者：
O'Brien KO
中科院分区：
文献类型：
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作者：
Cao C;Pressman EK;Cooper EM;Guillet R;Westerman M;O'Brien KO
低密度脂蛋白受体相关蛋白1 （LDL receptor related protein 1, LRP 1）是人胎盘中高表达的跨膜受体。最近发现它是血红素及其血浆结合蛋白血红素的受体，是全身血红素清除的组成部分。关于妊娠期间血凝素的全身浓度以及母体血凝素和胎盘LRP1是否有助于妊娠期间胎儿铁稳态，我们知之甚少。我们假设胎盘LRP1会在母体/新生儿铁不足中上调，并可能与母体循环血凝素有关。在57例（14-18岁）怀孕少女中，评估胎盘LRP1表达与母体和脐带血铁状态指标[血红蛋白、血清铁蛋白、转铁蛋白受体]、铁调节激素hepcidin和血清血凝素的关系。妊娠中期血红素与妊娠中期血红蛋白呈正相关（r = 0.35, P = 0.02），分娩时血红素与脐带hepcidin呈正相关（r = 0.37, P = 0.005）。胎盘LRP1蛋白的表达在妊娠中期至足月血清血凝素明显下降的妇女中显著升高（r = 0.28, P = 0.04）。胎盘LRP1蛋白与脐带hepcidin （r = - 0.29, P = 0.03）和胎盘血红素输出FLVCR1 （r = 0.34, P = 0.03）之间也存在显著相关性。我们的数据与胎盘血红素铁利用在支持胎儿铁需求中的作用是一致的。
LDL receptor-related protein 1 (LRP 1) is a transmembrane receptor highly expressed in human placenta. It was recently found to be the receptor for heme and its plasma binding protein hemopexin and is integral to systemic heme clearance. Little is known about systemic concentrations of hemopexin during pregnancy and whether maternal hemopexin and placental LRP1 contributes to fetal iron homeostasis during pregnancy. We hypothesized that placental LRP1 would be up-regulated in maternal/neonatal iron insufficiency and would be related to maternal circulating hemopexin. Placental LRP1 expression was assessed in 57 pregnant adolescents (14–18 y) in relation to maternal and cord blood iron status indicators [hemoglobin, serum ferritin, transferrin receptor], the iron regulatory hormone hepcidin and serum hemopexin. Hemopexin at mid-gestation correlated positively with hemoglobin at mid-gestation (r = 0.35, P = 0.02) and hemopexin at delivery correlated positively with cord hepcidin (r = 0.37, P = 0.005). Placental LRP1 protein expression was significantly higher in women who exhibited greater decreases in serum hemopexin from mid-gestation to term (r = 0.28, P = 0.04). Significant associations were also found between placental LRP1 protein with cord hepcidin (r = − 0.29, P = 0.03) and placental heme exporter FLVCR1 (r = 0.34, P = 0.03). Our data are consistent with a role for placental heme iron utilization in supporting fetal iron demands.