IMMUNOGLOBULIN-V(H)3 GENE-PRODUCTS - NATURAL LIGANDS FOR HIV GP120
IMMUNOGLOBULIN-V(H)3 GENE-PRODUCTS - NATURAL LIGANDS FOR HIV GP120
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DOI：
10.1126/science.7690497
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发表时间：
1993-09-17
期刊：
影响因子：
56.9
通讯作者：
BRAUN, J
中科院分区：
文献类型：
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作者：
BERBERIAN, L;GOODGLICK, L;BRAUN, J
1型人类免疫缺陷病毒（HIV - 1）感染会耗尽表达CD4的T细胞以及表达免疫球蛋白（Ig）V（H）3基因产物的B细胞。来自未感染HIV个体的正常B细胞亚群被证明可通过膜表面Ig与HIV gp120结合；这些B细胞大多表达V（H）3家族Ig。未感染个体的血清V（H）3 IgM也能与gp120紧密结合。最后，gp120选择性地诱导V（H）3 B细胞分泌Ig，这表明gp120的结合可功能性激活这些细胞。这些结果表明，天然存在的V（H）3 Ig是gp120的第二种配体，也是V（H）3 B细胞的一种候选超抗原。
Infection with human immunodeficiency virus-type 1 (HIV-1) depletes T cells expressing CD4 and B cells expressing immunoglobulin (Ig) V(H)3 gene products. A subpopulation of normal B cells from non-HIV-infected individuals was shown to bind to HIV gp120 by means of membrane Ig; most of these B cells expressed V(H)3 family Ig. Serum V(H)3 IgM from uninfected individuals also avidly bound gp120. Finally, gp120 selectively induced Ig secretion by V(H)3 B cells, indicating that the binding of gp120 functionally activated these cells. These results indicate that naturally occurring V(H)3 Ig is a second ligand for gp120 and a candidate superantigen for V(H)3 B cells.