Clinicopathological features of serrated adenocarcinoma defined by Mäkinen in dukes' B colorectal carcinoma.
Clinicopathological features of serrated adenocarcinoma defined by Mäkinen in dukes' B colorectal carcinoma.
复制标题
Mäkinen 定义的 dukes B 结直肠癌锯齿状腺癌的临床病理学特征。
作者：
東守洋;得平道英;川口岳晴;竹内正博;大和田千佳子;中世古知明;武成英明;木崎昌弘;田丸淳一;Shida Y
目的分级腺癌（SAC）是一种新的病理类型，主要发生于结肠右侧，预后较常规结直肠癌差。结直肠癌在Dukes ' B中预后是可变的，因此本研究的目的是确定SAC在Dukes ' B中是否预后不良。方法研究组为64例行结直肠癌手术患者。我们对SAC和非SAC与性别、年龄、组织学类型、肿瘤深度、肿瘤位置、静脉浸润和淋巴浸润的关系进行了统计分析。结果11例患者中有17.5%出现sacs。SAC患者的5年生存率低于非SAC患者（p= 0.0396, Kaplan-Meier）。在单因素分析中达到统计学意义的因素随后被纳入多因素分析，我们发现SAC是一个独立因素（p= 0.027）。结论SAC预后较差，不受其他因素影响，证实SAC是一个独立的不良预后因素。
ObjectiveSerrated adenocarcinoma (SAC), proposed as a new pathologic type, arises predominantly in the right side of the colon and has a poorer prognosis than conventional colorectal carcinoma. The prognosis of colorectal carcinoma is variable in Dukes’ B, so the aim of this study was to determine whether or not SAC has a poor prognosis in Dukes’ B.MethodsThe study group comprised 64 patients who underwent surgery for colorectal carcinoma. We undertook a statistical analysis of the association of SAC and non-SAC with sex, age, histologic type, depth of tumor, location of tumor, venous invasion and lymphatic invasion.ResultsSACs were encountered in 17.5% of cases (n= 11). SAC had a less favorable 5-year survival than non-SAC (p= 0.0396 log-rank, Kaplan-Meier). The factors that achieved statistical significance in the univariate analysis were subsequently included in a multivariate analysis and we found that SAC was an independent factor (p= 0.027).ConclusionsSAC has a poor prognosis and is not affected by other factors confirming that SAC is an independently less favorable prognostic factor.