The roles of stem cell memory T cells in hematological malignancies.
The roles of stem cell memory T cells in hematological malignancies.
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DOI：
10.1186/s13045-015-0214-5
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发表时间：
2015-10-14
影响因子：
28.5
通讯作者：
Li Y
中科院分区：
文献类型：
--
作者：
Xu L;Zhang Y;Luo G;Li Y
收养细胞疗法（ACT）迅速从长凳上迁移到临床治疗，以进行血液恶性肿瘤。最近，记忆T细胞的新型亚型，即干细胞记忆T（TSCM）细胞，被证明是最有利的ACT子集之一。 TSCM具有很高的自我更新能力，并且与T细胞的植入，持久性和抗肿瘤免疫有关。在这篇综述中，我们专注于抗原特异性TSCM细胞的特征，并讨论了它们针对血液学恶性肿瘤的免疫疗法的潜力。
Adoptive cell therapy (ACT) is rapidly migrating from bench to clinical therapy for hematological malignancies. Recently, a new subtype of memory T cells, stem cell memory T (TSCM) cells, was shown to be one of the most favorable subsets for ACT. TSCM has high self-renewal capacity and is associated with superior T cell engraftment, persistence, and antitumor immunity. In this review, we focused on the characteristics of antigen-specific TSCM cells and discussed their potential for immunotherapy targeting hematological malignancies.