DISAPPEARANCE OF HIGH-INCIDENCE AMYOTROPHIC LATERAL SCLEROSIS AND PARKINSONISM-DEMENTIA ON GUAM
DISAPPEARANCE OF HIGH-INCIDENCE AMYOTROPHIC LATERAL SCLEROSIS AND PARKINSONISM-DEMENTIA ON GUAM
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DOI：
10.1212/wnl.35.2.193
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发表时间：
1985-01-01
期刊：
影响因子：
9.9
通讯作者：
GAJDUSEK, DC
中科院分区：
文献类型：
--
作者：
GARRUTO, RM;YANAGIHARA, R;GAJDUSEK, DC
关岛查莫罗人肌萎缩侧索硬化症（ALS）和帕金森病痴呆（PD）的高发病率仅略高于美国。这种下降主要发生在男性中，尤其是那些出生于 1920 年之后、生活在大陆土壤和水中钙和镁含量较低的地区的男性。受影响患者的男女比例现在接近一致，而 3 年前 ALS 患者的男女比例为 2:1，PD 患者的男女比例为 3:1。以前的高发病率是由于矿物质代谢缺陷和继发性甲状旁腺功能亢进引起的，而继发性甲状旁腺功能亢进是由于C和Mg营养缺乏引起的，导致Ca和Al在神经元中沉积。
The high incidence rates of amyotrophic lateral sclerosis (ALS) and parkinsonism-dementia (PD) occurring among the Chamorros of Guam have delcined to rates only slightly higher than those observed in the USA. This decline has occurred principally among males, especially those born after 1920 and living in areas where continental calcium and magnesium levels are low in soil and water. The male-to-female ratio among affected patients now approaches unity, compared with ratios of 2-1 for ALS and 3-1 for PD 3 decades ago. The previously high incidence resulted from defects in mineral metabolism and secondary hyperparathyroidism, provoked by nutritional deficiencies of C and Mg, with resultant deposition of Ca and Al in neurons.