New estimator of the genotype risk ratio for use in case-parental control studies.
New estimator of the genotype risk ratio for use in case-parental control studies.
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DOI：
10.1093/aje/154.3.259
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发表时间：
2001-08
影响因子：
5
通讯作者：
W. Flanders;F. Sun;Q. Yang
中科院分区：
文献类型：
--
作者：
W. Flanders;F. Sun;Q. Yang
基因型风险比的估计可以是研究遗传学在疾病病因中的作用的重要部分。例如，我们可以将基因型DD的人的风险与基因型Dd的人的风险进行比较，其中候选基因座具有等位基因D和d，D代表疾病易感性等位基因。在本文中，作者提出了一种改进的分析方法的情况下，父母控制的研究，可以提高效率。他们展示了研究人员如何使用来自父母双方都被观察到的家庭的信息来改进Sun等人创建的估计量，这适用于仅观察到一个亲本和一个受影响的后代的情况。由于Schaid和Sommer的条件方法不使用此信息，因此作者的方法允许更完整地使用可用信息，从而导致基因型风险比估计值的均方误差较小。作者还提出了一种方法来结合联合收割机估计家庭中的一个父母和一个后代的观察和估计家庭中的父母和一个后代的观察。
Estimation of the genotype risk ratio can be an important part of studying the role of genetics in disease causation. For example, one might estimate risk among persons with genotype DD compared with risk among those with genotype Dd, where the candidate locus has alleles D and d, with D representing the disease susceptibility allele. In this paper, the authors propose a modified method of analysis for case-parental control studies that can improve efficiency. They show how investigators can use information from families in which both parents are observed to improve the estimator created by Sun et al., which applies when only one parent and an affected offspring have been observed. Since this information is not used by the conditional approach of Schaid and Sommer, the authors' approach allows for more complete use of available information, leading to a smaller mean squared error of the genotype risk ratio estimators. The authors also suggest a way to combine estimates from families in which one parent and one offspring are observed and estimates from families in which both parents and one offspring are observed.