Trend of increase in the incidence of acute myocardial infarction in a Japanese population
Trend of increase in the incidence of acute myocardial infarction in a Japanese population
复制标题
DOI：
10.1093/aje/kwn064
复制
发表时间：
2008-06-01
影响因子：
5
通讯作者：
Ueshima, Hirotsugu
中科院分区：
文献类型：
--
作者：
Rumana, Nahid;Kita, Yoshikuni;Ueshima, Hirotsugu
日本的急性心肌梗死（AMI）的发病率和死亡率仍然很低，尽管有重大的饮食变化和心血管危险因素的恶化，这种情况应该导致AMI率大幅增加（日本悖论）。利用高岛AMI登记处的数据，研究了1990-2001年期间AMI发病率的当前趋势，该登记处覆盖了日本中部约55，000名稳定人群。计算1990-1992年、1993-1995年、1996-1998年和1999-2001年的AMI发病率（每10万人-年）和95%置信区间。发病率趋势是通过计算各年的平均年变化百分比确定的。在1990-2001年期间，有352例（男性：n = 224;女性：n = 128）登记的首次AMI病例。所有AMI的年龄校正发病率显示从1990-1992年的39.9（95%置信区间（CI）：29.8，50.0）逐渐增加到1999-2001年的62.6（95% CI：51.5，73.7）。在男性中，年龄调整的发病率从1990-1992年的66.5（95% CI：46.4，86.6）增加到1999-2001年的100.7（95% CI：78.6，122.7）。在女性中，在最初急剧增加后观察到波动。男性的年平均发病率增加了7.6%（95% CI：3.5，11.7），女性增加了8.3%（95% CI：1.02，15.6）。据作者所知，这是第一项报告日本人群中AMI呈上升趋势的研究。
The incidence and mortality of acute myocardial infarction (AMI) remain low in Japan despite major dietary changes and worsening cardiovascular risk factors, a situation that should have resulted in a substantial increase in AMI rates (Japanese paradox). The current trend in the incidence of AMI was examined for the period 1990-2001 by use of data from the Takashima AMI Registry covering a stable population of approximately 55,000 in central Japan. AMI incidence rates (per 100,000 person-years) and 95% confidence intervals were calculated for 1990-1992, 1993-1995, 1996-1998, and 1999-2001. The incidence trend was determined by calculating the average annual change in percentage across the years. There were 352 (men: n = 224; women: n = 128) registered first-ever AMI cases during 1990-2001. The age-adjusted incidence rate of all AMI showed a gradual increase from 39.9 (95% confidence interval (CI): 29.8, 50.0) in 1990-1992 to 62.6 (95% CI: 51.5, 73.7) in 1999-2001. In men, the age-adjusted incidence rate increased from 66.5 (95% CI: 46.4, 86.6) in 1990-1992 to 100.7 (95% CI: 78.6, 122.7) in 1999-2001. In women, fluctuation was observed after an initial steep increase. The average annual incidence increased by 7.6% (95% CI: 3.5, 11.7) among men and by 8.3% (95% CI: 1.02, 15.6) among women. To the best of the authors' knowledge, this is the first study to report an increasing trend of AMI in a Japanese population.