Determinants of the renal clearance of digoxin
Determinants of the renal clearance of digoxin
复制标题
地高辛肾清除率的决定因素
DOI：
10.1002/cpt1975174385
复制
发表时间：
1975
影响因子：
6.7
通讯作者：
Kenneth L. Melmon
中科院分区：
文献类型：
--
作者：
Hillel Halkin;Lewis B. Sheiner;Carl C. Peck;Kenneth L. Melmon
同时测定了接受地高辛治疗的41名患者的肾脏地高辛、肌酐和尿素氮的清除情况，其中大多数患者存在肾前性氮质血症。血尿素氮(RUN)26.1±12.8 mg/100ml，肌酐1.1±0041 mg/100ml，肌酐清除量78±42ml/min/1.73m2，地高辛清除量66.6±42.1ml/min/1.73m2，尿素氮清除量27.8±19.2ml/min/1.73m2。相关分析显示尿素清除量优于肌酐清除量，而RUN对地高辛清除量的影响程度优于血肌酐浓度。此外，使用偏相关技术，很明显地，在这些患者中，地高辛清除量与尿流率显著相关，而与肌酐清除量无关，与尿素氮清除量无关，与肌酐清除量和尿流率无关。这些发现与地高辛与过滤和分泌一样经历一定程度的管状重吸收的次要论断是一致的。
The renal clearances of digoxin, creatinine, and urea nitrogen were determined simultaneously in each of 41 patients receiving digoxin, in most of whom there was prerenal azotemia. Mean ± SD values were: blood urea nitrogen (RUN), 26.1 ± 12.8 mg per 100 ml; creatinine, 1.1 + 0041 mg per 100 ml; creatinine clearance, 78 ± 42 ml/min/1.73 m2; digoxin clearance, 66.6 ± 42.1 ml/min/1.73 m2; urea nitrogen clearance, 27.8 ± 19.2 ml/min/1.73 m2. Correlation analysis revealed that urea clearance is superior to creatinine clearance, and RUN is superior to serum creatinine concentration in the degree of relationship to renal digoxin clearance. Moreover, using partial correlation techniques, it is apparent that in these patients digoxin clearance was significantly related to urine flow rate independent of creatinine clearance, and to urea nitrogen clearance independent of both creatinine clearance and urine flow rate. These findings are compatible with the hypo thesis that digoxin undergoes some degree of tubular reabsorption as welt as filtration and secretion.