Effects of Fibrates in Kidney Disease
Effects of Fibrates in Kidney Disease
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DOI：
10.1016/j.jacc.2012.07.049
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发表时间：
2012-11-13
影响因子：
24
通讯作者：
Perkovic, Vlado
中科院分区：
文献类型：
--
作者：
Jun, Min;Zhu, Bin;Perkovic, Vlado
Objectives The purpose of this systematic review and meta-analysis was to determine the efficacy and safety of fibrate therapy in the chronic kidney disease (CKD) population.Background Fibrate therapy produces modest cardiovascular benefits in people at elevated cardiovascular risk. There is limited evidence about the clinical benefits and safety of fibrate therapy in the CKD population.Methods MEDLINE, EMBASE, and the Cochrane Library were systematically searched (1950 to January 2012) for prospective randomized controlled trials assessing the effects of fibrate therapy compared with placebo in people with CKD or on kidney-related outcomes were included.Results Ten studies including 16,869 participants were identified. In patients with mild-to-moderate CKD (estimated glomerular filtration rate [eGFR]
