Effects of Antifungal Agents Alone and in Combination Against Candida glabrata Strains Susceptible or Resistant to Fluconazole
Effects of Antifungal Agents Alone and in Combination Against Candida glabrata Strains Susceptible or Resistant to Fluconazole
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DOI：
10.1007/s11046-012-9538-7
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发表时间：
2012-09-01
期刊：
影响因子：
5.5
通讯作者：
Alves, Sydney Hartz
中科院分区：
文献类型：
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作者：
Alves, Izabel Almeida;Bandeira, Laissa Arevalo;Alves, Sydney Hartz
念珠菌的崛起对经典的三唑类抗真菌剂的抗性导致了对新的治疗选择的探索。在这里，我们评估了抗真菌药的组合，在棋盘测定对两组光滑念珠菌菌株：一个含有氟康唑敏感的临床分离株（FS），另一个含有氟康唑耐药的实验室衍生物（FR）。观察到的最大协同作用组合是阿替霉素B +氟胞嘧啶（对61.77%的FS菌株和76.47%的FR菌株具有协同作用）.观察到最具拮抗作用的联合用药是酮康唑+氟胞嘧啶（FS 61.77%和FR 55.88%）。令人惊讶的是，大多数组合证明了无差异的相互作用，并且最佳协同作用出现在当阿替霉素B和氟胞嘧啶组合对抗两组分离株时。
The rise of Candida spp. resistant to classic triazole antifungal agents has led to a search for new therapeutic options. Here, we evaluated combinations of antifungals in a checkerboard assay against two groups of Candida glabrata strains: one containing fluconazole-susceptible clinical isolates (FS) and another containing fluconazole-resistant laboratory derivative (FR). The most synergistic combination observed was amphotericin B + flucytosine (synergistic for 61.77 % of FS strains and 76.47 % of FR strains). The most antagonistic combination observed was ketoconazole + flucytosine (FS 61.77 % and FR 55.88 %). Surprisingly, most combinations evidenced indifferent interactions, and the best synergism appeared when amphotericin B and flucytosine were combined against both groups of isolates.