Contribution of adipocytokines to low-grade inflammatory state as expressed by circulating C-reactive protein in Japanese men: Comparison of leptin and adiponectin
Contribution of adipocytokines to low-grade inflammatory state as expressed by circulating C-reactive protein in Japanese men: Comparison of leptin and adiponectin
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DOI：
10.1016/j.ijcard.2008.01.006
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发表时间：
2008-11-12
影响因子：
3.5
通讯作者：
Toyoshima, Hideaki
中科院分区：
文献类型：
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作者：
Sugiura, Kaichiro;Tamakoshi, Koji;Toyoshima, Hideaki
背景：循环C反应蛋白（CRP）是炎症的标志物，与心血管事件的发生有关。虽然它已被称为脂联素保护，而瘦素加速，动脉粥样硬化疾病的发展，其相互影响的比较强度对循环CRP仍不清楚。方法：我们研究了一个人口2049日本男性年龄在35至66岁。对所有受试者进行多元回归分析，以对数转换的CRP浓度为因变量，以对数转换的瘦素、对数转换的脂联素、年龄、BMI、吸烟状况和代谢综合征组分为自变量。瘦素标准化回归系数（st-β）的绝对值（st-β = 0.201）高于脂联素（st-β = -0.082）。按当前BMI分层后，BMI < 25 kg/m2的受试者中，两种脂肪细胞因子与CRP浓度显著相关，而BMI ≥ 25 kg/m2的受试者中，只有瘦素与CRP浓度显著相关。瘦素与CRP水平的相关性比脂联素更强，尤其是在肥胖者中。(C)2008爱思唯尔爱尔兰有限公司保留所有权利。
Background: Circulating C-reactive protein (CRP) is a marker of inflammation and is associated with the incidence of cardiovascular events. Although it has been known that adiponectin protects, whereas leptin accelerates, the development of atherosclerotic diseases, the comparative strength of their reciprocal effects on circulating CRP remains unclear.Methods: We studied a population of 2049 Japanese men aged 35 to 66. For all subjects, multiple regression analysis performed with log-transformed CRP concentration as the dependent variable, and with log-transformed leptin, log-transformed adiponectin, age, BMI, smoking status, and components of metabolic syndrome as independent variables.Results: Both leptin (positively) and adiponectin (negatively) were significantly and independently associated with CRP concentration. The absolute value of the standardized regression coefficient (st-beta) of leptin (st-beta = 0.201) was higher than that of adiponectin (st-beta = -0.082). After subjects were stratified by current BMI level, both of the adipocytokines were significantly associated with CRP concentration among subjects with BMI < 25 kg/m(2), whereas only leptin was significantly associated with CRP concentration among subjects with BMI > = 25 kg/m(2).Conclusions: Both leptin and adiponectin were independently associated with CRP concentration. Leptin was more strongly related to CRP levels than adiponectin was, especially among obese subjects. (C) 2008 Elsevier Ireland Ltd. All rights reserved.