Bioactivity, Health Benefits, and Related Molecular Mechanisms of Curcumin: Current Progress, Challenges, and Perspectives.
Bioactivity, Health Benefits, and Related Molecular Mechanisms of Curcumin: Current Progress, Challenges, and Perspectives.
复制标题
DOI：
10.3390/nu10101553
复制
发表时间：
2018-10-19
期刊：
影响因子：
5.9
通讯作者：
Li HB
中科院分区：
文献类型：
--
作者：
Xu XY;Meng X;Li S;Gan RY;Li Y;Li HB
姜黄素是姜黄（Curcuma longa）的主要姜黄素类化合物，其通常用作烹饪中的香料和食品加工工业中的黄色色素。近年来的研究表明，姜黄素具有多种生物活性和药理性能，对人体健康具有保护和促进作用。本文综述了姜黄素的肠道代谢，综述了姜黄素的抗氧化、抗炎、免疫调节等多种生物活性的研究进展，并重点讨论了姜黄素对癌症、糖尿病、肝脏、神经系统和心血管系统的保护或预防作用。突出潜在的分子机制。此外，基于临床试验，进一步阐述了姜黄素对人体的有益作用。考虑到姜黄素的有益作用仍有争议，我们还讨论了相关的挑战和前景。总的来说，姜黄素是一种很有前途的新型功能食品成分，具有预防某些疾病的保护作用。我们希望这一全面和最新的审查将有助于促进以人为本的研究，以促进其在人类健康和疾病的未来使用。
Curcumin is a principal curcuminoid of turmeric (Curcuma longa), which is commonly used as a spice in cooking and a yellow pigment in the food processing industry. Recent studies have demonstrated that curcumin has a variety of biological activities and pharmacological performances, providing protection and promotion of human health. In addition to presenting an overview of the gut metabolism of curcumin, this paper reviews the current research progress on its versatile bioactivity, such as antioxidant, anti-inflammatory, and immune-regulatory activities, and also intensively discusses its health benefits, including the protective or preventive effects on cancers and diabetes, as well as the liver, nervous system, and cardiovascular systems, highlighting the potential molecular mechanisms. Besides, the beneficial effects of curcumin on human are further stated based on clinical trials. Considering that there is still a debate on the beneficial effects of curcumin, we also discuss related challenges and prospects. Overall, curcumin is a promising ingredient of novel functional foods, with protective efficacy in preventing certain diseases. We hope this comprehensive and updated review will be helpful for promoting human-based studies to facilitate its use in human health and diseases in the future.