Optical planar waveguide for cell counting.
Optical planar waveguide for cell counting.
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DOI：
10.1063/1.3678339
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发表时间：
2012-01
影响因子：
4
通讯作者：
J. LeBlanc;A. J. Mueller;A. Prinz;M. Butte
中科院分区：
文献类型：
--
作者：
J. LeBlanc;A. J. Mueller;A. Prinz;M. Butte
细胞的低成本计数在筛查、军事医学、灾难医学和农村医疗保健中具有医学应用。在这份报告中，我们提出了一个浅，埋，平面波导制作钾离子交换玻璃，使低成本和快速计数的金属标记的对象，位于波导的倏逝场。通过波导传输的激光衰减成比例的存在下的金属涂层的微结构制造的光致抗蚀剂。该技术能够低成本地从血液、尿液或其他生物流体中计数细胞。
Low cost counting of cells has medical applications in screening, military medicine, disaster medicine, and rural healthcare. In this report, we present a shallow, buried, planar waveguide fabricated by potassium ion exchange in glass that enables low-cost and rapid counting of metal-tagged objects that lie in the evanescent field of the waveguide. Laser light transmitted through the waveguide was attenuated proportionately to the presence of metal-coated microstructures fabricated from photoresist. This technology enables the low-cost enumeration of cells from blood, urine, or other biofluids.