Functional neuroimaging of treatment effects in psychiatry: methodological challenges and recommendations.
Functional neuroimaging of treatment effects in psychiatry: methodological challenges and recommendations.
复制标题
DOI：
10.3109/00207454.2012.678446
复制
发表时间：
2012-09
期刊：
影响因子：
--
通讯作者：
Bodfish JW
中科院分区：
文献类型：
--
作者：
Dichter GS;Sikich L;Song A;Voyvodic J;Bodfish JW
功能磁共振成像(FMRI)通过定位脑功能中与病因相关的异常，有助于阐明精神和神经发育障碍的神经生物学基础。功能磁共振成像也显示出巨大的希望，可以帮助理解一系列精神和神经发育障碍有效治疗的潜在作用机制，包括情绪和焦虑症、精神分裂症和自闭症。然而，使用功能磁共振成像来探索精神病学中的干预效果与独特的方法学考虑有关，包括重复功能磁共振成像扫描的心理测量学特性，如何评估干预对症状的影响和特定大脑激活模式之间的潜在关系，以及如何最好地对干预对大脑功能的影响做出因果推断。此外，对神经发育障碍的治疗效果的研究还提出了与大脑成熟、分析方法和运动伪影的可能性有关的额外的独特挑战。我们回顾了这些方法学方面的考虑，并为每个主题提供了最佳实践的建议。
Functional magnetic resonance imaging (fMRI) has helped to elucidate the neurobiological bases of psychiatric and neurodevelopmental disorders by localizing etiologically-relevant aberrations in brain function. Functional MRI also has shown great promise to help understand potential mechanisms of action of effective treatments for a range of psychiatric and neurodevelopmental disorders, including mood and anxiety disorders, schizophrenia, and autism. However, the use of fMRI to probe intervention effects in psychiatry is associated with unique methodological considerations, including the psychometric properties of repeated fMRI scans, how to assess potential relations between the effects of an intervention on symptoms and on specific brain activation patterns, and how to best make causal inferences about intervention effects on brain function. Additionally, the study of treatment effects in neurodevelopmental disorders presents additional unique challenges related to brain maturation, analysis methods, and the potential for motion artifacts. We review these methodological considerations and provide recommendations for best practices for each of these topics.