TANDEM: matching proteins with tandem mass spectra
TANDEM: matching proteins with tandem mass spectra
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DOI：
10.1093/bioinformatics/bth092
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发表时间：
2004-06-12
期刊：
影响因子：
5.8
通讯作者：
Beavis, RC
中科院分区：
文献类型：
--
作者：
Craig, R;Beavis, RC
通过裂解多肽离子获得的串联质谱图包含了一些多肽序列特有的信息，但往往没有足够的信息来对原始多肽进行完整的测序。已经开发了几个专有软件应用程序来尝试将光谱与可能包含肽序列的蛋白质序列列表进行匹配。编写应用程序Tandem是为了向蛋白质组学研究团体提供一组组件，这些组件可用于测试执行这种类型的序列到数据匹配的新方法和算法。
Tandem mass spectra obtained from fragmenting peptide ions contain some peptide sequence specific information, but often there is not enough information to sequence the original peptide completely. Several proprietary software applications have been developed to attempt to match the spectra with a list of protein sequences that may contain the sequence of the peptide. The application TANDEM was written to provide the proteomics research community with a set of components that can be used to test new methods and algorithms for performing this type of sequence-to-data matching.