Bisphosphonate-related osteonecrosis of jaw (BRONJ): an anti-angiogenic side-effect?
Bisphosphonate-related osteonecrosis of jaw (BRONJ): an anti-angiogenic side-effect?
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DOI：
10.1186/1746-1596-7-78
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发表时间：
2012-07-06
影响因子：
2.6
通讯作者：
Brinzaniuc K
中科院分区：
文献类型：
--
作者：
Petcu EB;Ivanovski S;Wright RG;Slevin M;Miroiu RI;Brinzaniuc K
双膦酸盐被推荐用于治疗骨质疏松症和某些癌症，在这种情况下，它们可以防止骨转移的出现。服用双膦酸盐的患者发生双膦酸盐相关性颌骨骨坏死（BRONJ）的风险增加，其特征是牙科手术后存在无法愈合的伤口。BRONJ可能代表一种抗血管生成的副作用。然而，BRONJ患者的实际人数可能比目前记录的要高。考虑到鉴别诊断包括各种原发性和继发性癌症，正确的组织病理学诊断是非常重要的。本材料强调了BRONJ诊断的形态学标准。本文的虚拟幻灯片可以在这里找到：http://www.diagnosticpathology.diagnomx.eu/vs/1813972972323288
Bisphosphonates are recommended in the treatment of osteoporosis and some cancers, in which case they prevent the appearance of bone metastasis. The patients taking bisphosphonates are at increased risk of developing bisphosphonate-related osteonecrosis of jaw (BRONJ) which is characterised by the presence of an un-healing wound after dental surgery. BRONJ might represent an anti-angiogenic side effect. However, the real number of patients with BRONJ might be higher than currently recorded. Considering the differential diagnosis which includes various primary and secondary cancers, a correct histopathological diagnosis is very important. The morphological criteria for diagnosis of BRONJ are highlighted in this material. The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1813972972323288
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影响因子：
3.5
作者：
Ferretti, G;Fabi, A;Cognetti, F
通讯作者：
Cognetti, F
影响因子：
8.4
作者：
Neville-Webbe, H. L.;Coleman, R. E.
通讯作者：
Coleman, R. E.
DOI：
10.1007/978-3-642-21892-7_3
发表时间：
2012-01-01
期刊：
PREVENTION OF BONE METASTASES
影响因子：
--
作者：
Gnant, Michael;Dubsky, Peter;Hadji, Peyman
通讯作者：
Hadji, Peyman
影响因子：
6.4
作者：
Tang, Xudong;Zhang, Qunzhou;Shi, Shihong;Yen, Yun;Li, Xiangyong;Zhang, Yuefei;Zhou, Keyuan;Le, Anh D.
通讯作者：
Le, Anh D.
DOI：
10.1007/978-3-642-21892-7_4
发表时间：
2012-01-01
期刊：
PREVENTION OF BONE METASTASES
影响因子：
--
作者：
Decoster, Lynn;de Marinis, Filippo;Nackaerts, Kristiaan
通讯作者：
Nackaerts, Kristiaan