Studies on the formation of Heinz bodies. I. Methemoglobin production and oxyhemoglobin destruction.
Studies on the formation of Heinz bodies. I. Methemoglobin production and oxyhemoglobin destruction.
复制标题
亨氏小体形成的研究。
作者：
John D. Harley;Alvin M. Mauer
已报告了一项对与各种供试物质孵育的红细胞血红蛋白变化的研究。测量这些红细胞中氧合血红蛋白和高铁血红蛋白的浓度，并引入术语“完整”血红蛋白，以将这些色素与血红蛋白的后期降解产物区分开。已知在体内引起海因茨小体形成和红细胞破坏的某些试剂已显示在体外引起高铁血红蛋白形成和“完整”血红蛋白破坏，并且这些试剂中的一些也显示在体内产生这些变化。这些发现的可能意义有关的作用高铁血红蛋白形成的海因茨体生产进行了讨论。
A study of the changes in hemoglobin of erythrocytes incubated with various test substances has been reported. The concentrations of oxyhemoglobin and methemoglobin in these erythrocytes were measured and the term "intact" hemoglobin was introduced, in order to distinguish these pigments from later degradation products of hemoglobin. Certain agents which are known to cause Heinz body formation and erythrocyte destruction in vivo have been shown to cause methemoglobin formation and "intact" hemoglobin destruction in vitro, and some of these agents were also shown to produce these changes in vivo. The possible significance of these findings in relation to the role of methemoglobin formation in Heinz body production has been discussed.