X-Ray Markers for Thin Film Implants.
X-Ray Markers for Thin Film Implants.
复制标题
用于薄膜植入物的 X 射线标记。
DOI：
10.1002/adhm.202200739
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发表时间：
2022
影响因子：
10
通讯作者：
Woodington BJ
中科院分区：
文献类型：
--
作者：
Woodington BJ
植入式电子医疗设备用于在手术前绘制大脑功能图，并提供神经调节以治疗神经系统和神经精神疾病。它们的电极阵列是手工组装的，这导致体积庞大、灵活性有限且电极数量少。使用微加工技术制造的薄膜植入物正在成为一种有吸引力的替代品，因为它们可显着提高适形性并实现高密度记录和刺激。然而，这些设备的一个主要限制是它们对于透视检查是不可见的，透视检查是用于监测可植入电极插入的最常用方法。在此，报道了使用注入铋和钡的弹性体开发机械柔性 X 射线标记物。对它们在人体尸体中的 X 射线衰减特性进行了探索，结果表明它们在细胞培养物中具有生物相容性。进一步表明它们不会扭曲磁共振成像图像，并且证明了它们与薄膜植入物的集成。这项工作消除了在大脑绘图和神经调节中采用薄膜植入物的关键障碍。
Implantable electronic medical devices are used in functional mapping of the brain before surgery and to deliver neuromodulation for the treatment of neurological and neuropsychiatric disorders. Their electrode arrays are assembled by hand, and this leads to bulky form factors with limited flexibility and low electrode counts. Thin film implants, made using microfabrication techniques, are emerging as an attractive alternative, as they offer dramatically improved conformability and enable high density recording and stimulation. A major limitation of these devices, however, is that they are invisible to fluoroscopy, the most common method used to monitor the insertion of implantable electrodes. Here, the development of mechanically flexible X‐ray markers using bismuth‐ and barium‐infused elastomers is reported. Their X‐ray attenuation properties in human cadavers are explored and it is shown that they are biocompatible in cell cultures. It is further shown that they do not distort magnetic resonance imaging images and their integration with thin film implants is demonstrated. This work removes a key barrier for the adoption of thin film implants in brain mapping and in neuromodulation.