Exposure to cat allergen, maternal history of asthma, and wheezing in first 5 years of life
Exposure to cat allergen, maternal history of asthma, and wheezing in first 5 years of life
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DOI：
10.1016/s0140-6736(02)09906-3
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发表时间：
2002-09-07
期刊：
影响因子：
168.9
通讯作者：
Gold, DR
中科院分区：
文献类型：
--
作者：
Celedón, JC;Litonjua, AA;Gold, DR
我们在母亲或父亲有或没有哮喘病史的儿童中寻找早期接触宠物与哮喘和喘息之间的联系。我们跟踪了448名儿童，他们的父母至少有一人有特应性过敏症的病史，从出生到5年。在母亲没有哮喘病史的儿童中，在2-3个月大时暴露在猫或FELD-1浓度至少8微克/克的环境中，与1-5岁期间喘息的风险降低有关。然而，在母亲确实有哮喘史的儿童中，这种暴露与3岁或3岁后喘息的风险增加有关。喘息与接触狗或狗过敏原之间没有关联，父亲的过敏状态也没有影响儿童喘息和猫接触之间的关系。
We looked for an association between early exposure to pets and asthma and wheezing in children whose mothers or fathers did or did not have a history of asthma. We followed up 448 children, who had at least one parent with a history of atopy, from birth to 5 years. Among children whose mothers had no history of asthma, exposure to a cat or a Fel d 1 concentration of at least 8 mug/g at the age of 2-3 months was associated with a reduced risk of wheezing between the ages of 1 and 5 years. However, among children whose mothers did have a history of asthma, such exposures were associated with an increased risk of wheezing at or after the age of 3 years. There was no association between wheezing and exposure to dog or dog allergen, and the father's allergy status had no effect on the relation between childhood wheezing and cat exposure.