DUCTAL CANCERS OF THE PANCREAS FREQUENTLY EXPRESS MARKERS OF GASTROINTESTINAL EPITHELIAL-CELLS
DUCTAL CANCERS OF THE PANCREAS FREQUENTLY EXPRESS MARKERS OF GASTROINTESTINAL EPITHELIAL-CELLS
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DOI：
10.1016/0016-5085(90)91104-e
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发表时间：
1990-06-01
期刊：
影响因子：
29.4
通讯作者：
SAMLOFF, IM
中科院分区：
文献类型：
--
作者：
SESSA, F;BONATO, M;SAMLOFF, IM
免疫组织化学染色发现，通常在胃和/或肠上皮细胞中发现的抗原在大多数分化的胰腺管细胞癌中表达。88例肿瘤中，分别有93%和92%的肿瘤表达胃表面-小窝上皮细胞标志物M1和组织蛋白酶E， 51%的肿瘤表达胃十二指肠黏液上皮细胞标志物胃蛋白酶原II， 48%的肿瘤表达结肠上皮细胞标志物CAR-5, 35%的肿瘤表达小肠杯状细胞标志物M3SI。大多数肿瘤也表达正常的胰管抗原；97%表达DU-PAN-2, 59%表达n端胃泌素释放肽。电镜显示，恶性细胞具有良好的结构特征，包括胃小凹细胞、胃粘膜上皮细胞、肠杯状细胞、肠柱状细胞、胰管上皮细胞，以及具有多种细胞类型特征的细胞。正常胰管上皮不表达任何胃肠道上皮细胞标记物，而粘液细胞肥大和乳头状增生等良性病变通常表达肠型抗原，但很少表达胰管细胞标记物。相反，以不典型乳头状增生为特征的病变通常同时表达胃和胰管细胞标记物。化生幽门型腺体表达胃蛋白酶原II，除了表达组织蛋白酶E外，与正常幽门腺体难以区分。14例导管腺泡细胞肿瘤的免疫组织化学和超微结构特征为末端小管、中央腺泡细胞、和/或腺泡细胞和/或腺泡细胞；没有表达任何肠道型抗原。结果表明，胃肠道分化在胰管上皮良恶性病变中都很常见，并提示胰管细胞癌与胰腺主小叶管和小叶间管上皮细胞的胃型和肠型化生变化有关。
It has been found by immunohistochemical staining that antigens normally found in gastric and/or intestinal epithelial cells are expressed in most differentiated duct cell carcinomas of the pancreas. Among 88 such tumors, 93% and 92%, respectively, expressed M1 and cathepsin E, markers of gastric surface-foveolar epithelial cells, 51% expressed pepsinogen II, a marker of gastroduodenal mucopeptic cells, 48% expressed CAR-5, a marker of colorectal epithelial cells, and 35% expressed M3SI, a marker of small intestinal goblet cells. Most of the tumors also expressed normal pancreatic duct antigens; 97% expressed DU-PAN-2, and 59% expressed N-terminus gastrin-releasing peptide. In agreement with these findings, electron microscopy revealed malignant cells with fine structural features of gastric foveolar cells, gastric mucopeptic cells, intestinal goblet cells, intestinal columnar cells, pancreatic duct epithelial cells, and cells with features of more than one cell type. Normal pancreatic duct epithelium did not express any marker of gastrointestinal epithelial cells, whereas such benign lesions as mucinous cell hypertrophy and papillary hyperplasia commonly expressed gut-type antigens but rarely expressed pancreatic duct cell markers. By contrast, lesions characterized by atypical papillary hyperplasia commonly expressed both gastric and pancreatic duct cell markers. Metaplastic pyloric-type glands expressed pepsinogen II and, except for their expression of cathepsin E, were indistinguishable from normal pyloric glands. In marked contrast, the immunohistochemical and ultrastructural features of 14 ductuloacinar cell tumors were those of cell lining terminal ductules, centroacinar cells, and/or acinar cells, and/or acinar cells; none expressed any gut-type antigen. The results indicate that gastrointestinal differentiation is common in both benign and malignant lesions of pancreatic duct epithelium and suggest that duct cell carcinomas are histogenetically related to gastric and intestinal-type metaplastic changes of epithelial cells lining the main and interlobular ducts of the pancreas.