Comparison of the amount of pectin in the human terminal ileum with the amount of orally administered pectin
Comparison of the amount of pectin in the human terminal ileum with the amount of orally administered pectin
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DOI：
10.1016/j.nut.2005.01.005
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发表时间：
2005-09-01
期刊：
影响因子：
4.4
通讯作者：
Sugawara, K
中科院分区：
文献类型：
--
作者：
Saito, D;Nakaji, S;Sugawara, K
目的：根据定义，膳食纤维在人体小肠中是难以消化和吸收的，它应该自然地到达大肠。到目前为止，已经有几篇报告研究了体内有多少膳食纤维通过葡萄糖到达人类受试者的回肠末端，结果差异很大。我们比较了人类回肠末端的果胶含量和口服果胶的含量。方法：7名20至27岁的健康男性志愿者被给予含有4.05 g果胶的试验餐。采用内窥镜逆行插肠法在回肠末端置入双腔管，通过管抽吸回肠内容物。口服给药的果胶量和从回肠末端收集的果胶量被估计为半乳糖醛酸浓度（Englyst的方法），并相互比较。结果：回肠末端收集的果胶平均+/-标准差为3.58 +/- 0.43 g，占给药果胶的88.4 +/- 10.5%。回收率在76.8% ~ 105.1%之间，个体差异较大。结论：在本研究中，大约90%的摄入果胶在回肠末端被回收。10%可能已经被消化道内的细菌降解，尤其是回肠末端。(c) 2005爱思唯尔公司版权所有。
Objective: Dietary fiber by definition is resistant to digestion and absorption in the human small intestine, and it should naturally reach the large intestine. To date, there have been several reports that have examined in vivo how much dietary fiber actually reaches the terminal ileum in human subjects using glucose, with large differences in results. We compared the amount of pectin in the human terminal ileum with that of orally administered pectin.Methods: Seven healthy male volunteers ages 20 to 27 y were given a test meal containing 4.05 g of pectin. A double-lumen tube was placed in the terminal ileum by using the endoscopic retrograde bowel insertion method, and the ileal contents were aspirated through the tube. Amounts of pectin orally administered and collected from the terminal ileum were estimated as galacturonic acid concentrations (Englyst's method) and were compared with each other.Results: The mean +/- standard deviation amount of pectin collected in the terminal ileum was 3.58 +/- 0.43 g, or 88.4 +/- 10.5% of pectin administered. Further, there were large individual differences in recovery, ranging from 76.8% to 105.1%.Conclusions: Approximately 90% of ingested pectin was recovered in the terminal ileum in this study. Ten percent may have been degraded by bacteria within the digestive tract, especially the terminal ileum. (c) 2005 Elsevier Inc. All rights reserved.