Protein corona: Opportunities and challenges.

Protein corona: Opportunities and challenges.
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DOI:
10.1016/j.biocel.2016.01.005
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发表时间:
2016-06
期刊:
The international journal of biochemistry & cell biology
影响因子:
--
通讯作者:
Mahmoudi M
Mahmoudi M
中科院分区:
其他
文献类型:
--
作者:
Zanganeh S;Spitler R;Erfanzadeh M;Alkilany AM;Mahmoudi M

文献摘要

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在与生物体液接触时,不同类型的生物分子(例如蛋白质)吸附到纳米粒子上,形成蛋白质冠。涂层纳米颗粒的表面特性(就相关蛋白质的类型和数量而言)决定了它们与生物系统的相互作用,从而决定了生物命运、治疗效率和毒性。从这个角度来看,我们将重点关注蛋白质电晕领域的最新进展和陷阱。
In contact with biological fluids diverse type of biomolecules (e.g., proteins) adsorb onto nanoparticles forming protein corona. Surface properties of the coated nanoparticles, in terms of type and amount of associated proteins, dictate their interactions with biological systems and thus biological fate, therapeutic efficiency and toxicity. In this perspective, we will focus on the recent advances and pitfalls in the protein corona field.