The Role of the Polycystic Ovary Syndrome Susceptibility Locus D19S884 Allele 8 in Maternal Glycemia and Fetal Size
The Role of the Polycystic Ovary Syndrome Susceptibility Locus D19S884 Allele 8 in Maternal Glycemia and Fetal Size
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DOI：
10.1210/jc.2009-2718
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发表时间：
2010-07-01
影响因子：
5.8
通讯作者：
Urbanek, M.
中科院分区：
文献类型：
--
作者：
Ackerman, C. M.;Lowe, L. P.;Urbanek, M.
背景：胰岛素抵抗、2型糖尿病和代谢综合征在西方社会的高发病率及其对生活质量的影响强调了确定代谢性疾病潜在易感基因的重要性。多囊卵巢综合征(PCOS)易感基因D19S884等位基因8(A8)与PCOS家族中的胰岛素抵抗、β细胞功能障碍和其他代谢表型相关。目的：利用多民族高血糖和不良妊娠结局队列，评估D19S884A8与母体血糖和胎儿大小的相关性。设计：检验母体D19S884A8与母体结局(空腹、1小时和2小时血糖，以及口服葡萄糖耐量试验中的空腹和1小时C肽)以及胎儿和母体D19S884A8与胎儿结局(出生体重、身长、头围、皮褶总和、脂肪质量、脐带C肽、对象：我们分析了4424名高加索母亲和3347名北欧血统的后代，1957名泰国母亲和2089名曼谷后代，1208名非洲加勒比母亲和1209名巴巴多斯后代，以及774名西班牙裔母亲和762名来自加州贝尔弗劳尔的后代。结果：在调整混淆变量和多重检验后，母亲和胎儿D19S884A8均未显示出与任何被测结果相关的显著证据。结论：在普通产科人群中，多囊卵巢综合征易感基因D19S884A8不是影响妊娠期血糖或胎儿大小的主要因素。(临床内分泌代谢酶95：3242-3250,2010)
Context: The high incidence of insulin resistance, type 2 diabetes, and metabolic syndrome in Western societies and their impact on quality of life emphasize the importance of identifying underlying susceptibility loci for metabolic diseases. The polycystic ovary syndrome (PCOS) susceptibility locus D19S884 allele 8 (A8) is associated with measures of insulin resistance, beta-cell dysfunction, and other metabolic phenotypes in PCOS families. We now investigate the role of D19S884 A8 in pregnancy.Objective: Using the multiethnic Hyperglycemia and Adverse Pregnancy Outcome cohort, we assessed the associations of D19S884 A8 with measures of maternal glycemia and fetal size.Design: We tested for association of maternal D19S884 A8 with maternal outcomes (fasting, 1-h, and 2-h plasma glucose, and fasting and 1-h C-peptide from an oral glucose tolerance test) and fetal and maternal D19S884 A8 with fetal outcomes (birth weight, length, head circumference, sum of skin folds, fat mass, cord C-peptide, and 2-h neonatal plasma glucose).Subjects: We analyzed 4424 Caucasian mothers and 3347 offspring of northern European ancestry, 1957 Thai mothers and 2089 offspring from Bangkok, 1208 Afro-Caribbean mothers and 1209 offspring from Barbados, and 774 Hispanic mothers and 762 offspring from Bellflower, California.Results: After adjusting for confounding variables and multiple testing, neither maternal nor fetal D19S884 A8 showed significant evidence for association with any of the outcomes tested.Conclusions: The PCOS susceptibility locus, D19S884 A8, is not a major factor contributing to glycemia during pregnancy or fetal size in a general obstetric population. (J Clin Endocrinol Metab 95: 3242-3250, 2010)