Trafficking Ion Transporters to the Apical Membrane of Polarized Intestinal Enterocytes.
Trafficking Ion Transporters to the Apical Membrane of Polarized Intestinal Enterocytes.
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DOI：
10.1101/cshperspect.a027979
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发表时间：
2018-01-02
影响因子：
7.2
通讯作者：
Goldenring JR
中科院分区：
文献类型：
--
作者：
Engevik AC;Goldenring JR
胃肠道的上皮细胞需要不同的顶侧和基底侧区域才能正常发挥功能。运输和插入的酶和转运蛋白的顶端刷状缘的肠上皮细胞是必不可少的有效消化和吸收的营养。特定的关键离子转运蛋白被输送到顶端刷状缘，以促进液体和电解质的摄取。这些顶端转运蛋白的维持需要靶向递送和调节膜再循环。MYO5B失活突变引起的微绒毛包涵体病患者的顶端运输改变的检查导致了对顶端再循环系统的元素对顶端运输的调节的深入了解。在细胞培养和动物模型中MYO5B损失的建模已经导致Rab11a和Rab8a被认为是顶端刷状缘功能的关键调节因子。所有这些研究都证明了顶膜运输动力学在维持极化上皮细胞功能中的重要性。
Epithelial cells lining the gastrointestinal tract require distinct apical and basolateral domains to function properly. Trafficking and insertion of enzymes and transporters into the apical brush border of intestinal epithelial cells is essential for effective digestion and absorption of nutrients. Specific critical ion transporters are delivered to the apical brush border to facilitate fluid and electrolyte uptake. Maintenance of these apical transporters requires both targeted delivery and regulated membrane recycling. Examination of altered apical trafficking in patients with Microvillus Inclusion Disease caused by inactivating mutations in MYO5B has led to insights into the regulation of apical trafficking by elements of the apical recycling system. Modeling of MYO5B loss in cell culture and animal models has led to recognition of Rab11a and Rab8a as critical regulators of apical brush border function. All of these studies demonstrate the importance of apical membrane trafficking dynamics in maintenance of polarized epithelial cell function.
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影响因子：
7.8
作者：
Bartles, J R;Zheng, L;Li, A;Wierda, A;Chen, B
通讯作者：
Chen, B
DOI：
10.1083/jcb.200408165
发表时间：
2004-11-08
期刊：
The Journal of cell biology
影响因子：
--
作者：
Ang AL;Taguchi T;Francis S;Fölsch H;Murrells LJ;Pypaert M;Warren G;Mellman I
通讯作者：
Mellman I
DOI：
10.1107/s1744309105030836
发表时间：
2005-10-01
影响因子：
0.9
作者：
Ben Ammar, Y;Takeda, S;Wakabayashi, S
通讯作者：
Wakabayashi, S
影响因子：
3.3
作者：
Cha, Boyoung;Tse, Ming;Donowitz, Mark
通讯作者：
Donowitz, Mark
影响因子：
5.6
作者：
Anderson, CMH;Thwaites, DT
通讯作者：
Thwaites, DT