Prostate inflammation and its potential impact on prostate cancer: A current review
Prostate inflammation and its potential impact on prostate cancer: A current review
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DOI：
10.1002/jcb.21536
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发表时间：
2008-04-01
影响因子：
4
通讯作者：
Ratliff, Timothy L.
中科院分区：
文献类型：
--
作者：
Haverkamp, Jessica;Charbonneau, Bridget;Ratliff, Timothy L.
最近的研究已经确定了炎症在几种癌症（如肝癌、胃癌和大肠癌）的发展和进展中的作用。来自若干研究的数据显示可溶性炎症介质如细胞因子、趋化因子和生长因子之间的相关性。然而，炎症和前列腺癌之间的直接关系尚未确定。目前存在的两个主要障碍限制了对这种关系的研究，首先是可用于研究前列腺炎症的动物模型有限，其次是对前列腺中的炎症反应知之甚少。在这里，我们首先回顾了炎症和前列腺癌之间相关性的数据，并回顾了目前已知的前列腺炎症反应以及这种炎症对前列腺组织的影响。
Recent studies have identified a role for inflammation in the development and progression of several cancers, such as liver, stomach and the large intestine. Data from several studies has shown correlations between soluble inflammatory mediators, such as cytokines, chemokines and growth factors. However, a direct relationship between inflammation and prostate cancer has yet to be identified. Two major hurdles currently exist which limit the study of this relationship are first that animal models available for studying prostate inflammation are limited, and secondly that relatively little is known about the inflammatory response in the prostate. Here we first review the data demonstrating a correlation between inflammation and prostate cancer as well as review what is currently known about the inflammatory response in the prostate and the impact this inflammation has on the prostate tissue.