CORONAVIRUS INFECTION IN ACUTE LOWER RESPIRATORY-TRACT DISEASE OF INFANTS
CORONAVIRUS INFECTION IN ACUTE LOWER RESPIRATORY-TRACT DISEASE OF INFANTS
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DOI：
10.1093/infdis/130.5.502
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发表时间：
1974-01-01
影响因子：
6.4
通讯作者：
MUFSON, MA
中科院分区：
文献类型：
--
作者：
MCINTOSH, K;CHAO, RK;MUFSON, MA
对417例18个月以下住院儿童下呼吸道疾病进行血清学监测，发现34例(8.2%)感染冠状病毒(OC43和/或229E株)。在同一时间间隔内，13名对照婴儿中有一人被感染。有两个不同的时期，分别持续6周和14周，期间下呼吸道疾病的发病率高达18.9%。肺炎、毛细支气管炎患者冠状病毒感染的发生率高于腺病毒、流感、副流感病毒1、2型和鼻病毒，仅低于副流感病毒3型和呼吸道合胞病毒。从两名儿童肺炎急性期获得的冰冻鼻液中发现了与229E株血清学相似或相同的冠状病毒。
A serologic surveillance of lower respiratory tract disease in 417 hospitalized children under 18 months of age revealed infection with coronaviruses (strains OC43 and/or 229E) in 34 (8.2%). During the same interval, one of 13 control infants was infected. There were two distinct periods lasting six and 14 weeks, respectively, during which the incidence rose to as high as 18.9% of patients with lower respiratory tract disease. The incidence of coronavirus infection in patients with pneumonia and bronchiolitis was higher than the incidences of adenoviruses, influenza, parainfluenza viruses types 1 and 2, and rhinoviruses, and lower only than the incidences of parainfluenza virus type 3 and respiratory syncytial virus. Coronaviruses serologically similar or identical to strain 229E were recovered from frozen nasal washes obtained during the acute phase of pneumonia in two children.