Gut microbiota confers host resistance to obesity by metabolizing dietary polyunsaturated fatty acids
Gut microbiota confers host resistance to obesity by metabolizing dietary polyunsaturated fatty acids
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DOI：
10.1038/s41467-019-11978-0
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发表时间：
2019-09-05
影响因子：
16.6
通讯作者：
Kimura, Ikuo
中科院分区：
文献类型：
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作者：
Miyamoto, Junki;Igarashi, Miki;Kimura, Ikuo
肠道微生物区系调节饮食的影响，从而改变宿主新陈代谢和代谢紊乱的发生率。西方饮食中丰富的omega-6多不饱和脂肪酸(PUFA)的摄入量增加，导致肥胖和相关疾病。虽然近年来多不饱和脂肪酸在肠道微生物区系中的代谢途径已被阐明，但其对宿主生理功能的影响仍不清楚。在这里，我们证明了肠道微生物区系通过调节饮食中多不饱和脂肪酸的代谢，赋予宿主对高脂饮食(HFD)诱导的肥胖的抵抗力。补充10-羟基-顺-12-十八碳烯酸(HYA)，一种最初与亚油酸相关的肠道微生物代谢物，可以在不引发花生四烯酸介导的脂肪炎症的情况下减轻HFD诱导的小鼠肥胖，并通过游离脂肪酸受体改善代谢状况。此外，乳杆菌感染的小鼠在HYA水平升高时也表现出类似的效果。我们的发现阐明了肠道微生物区系和宿主能量代谢之间的相互作用，通过饮食中omega-6-FAs的代谢物，从而为通过靶向肠道微生物代谢物预防和治疗代谢紊乱提供了线索。
Gut microbiota mediates the effects of diet, thereby modifying host metabolism and the incidence of metabolic disorders. Increased consumption of omega-6 polyunsaturated fatty acid (PUFA) that is abundant in Western diet contributes to obesity and related diseases. Although gut-microbiota-related metabolic pathways of dietary PUFAs were recently elucidated, the effects on host physiological function remain unclear. Here, we demonstrate that gut microbiota confers host resistance to high-fat diet (HFD)-induced obesity by modulating dietary PUFAs metabolism. Supplementation of 10-hydroxy-cis-12-octadecenoic acid (HYA), an initial linoleic acid-related gut-microbial metabolite, attenuates HFD-induced obesity in mice without eliciting arachidonic acid-mediated adipose inflammation and by improving metabolic condition via free fatty acid receptors. Moreover, Lactobacillus-colonized mice show similar effects with elevated HYA levels. Our findings illustrate the interplay between gut microbiota and host energy metabolism via the metabolites of dietary omega-6-FAs thereby shedding light on the prevention and treatment of metabolic disorders by targeting gut microbial metabolites.