Distinct mechanisms promote polarity establishment in carpels of Arabidopsis
Distinct mechanisms promote polarity establishment in carpels of Arabidopsis
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DOI：
10.1016/s0092-8674(00)81651-7
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发表时间：
1999-10-15
期刊：
影响因子：
64.5
通讯作者：
Bowman, JL
中科院分区：
文献类型：
--
作者：
Eshed, Y;Baum, SF;Bowman, JL
植物的侧生器官表现出不对称性，其远轴特征由拟南芥 YABBY 基因家族的成员指定。仅当其他基因（例如 GYMNOS 或 KANADI）的功能也受到损害时，CRABS CLAW（该家族的创始成员）的突变才会表现出近轴心皮组织的异位形成。这些基因的突变本身不会导致极性分化的丧失，因此，它们与 CRABS CLAW 冗余地作用来建立极性。由于 GYMNOS 编码染色质重塑蛋白 Mi2 的一致表达同源物，因此我们认为独特的遗传相互作用并不反映分子冗余。相反，CRABS CLAW 在空间上调节转录，而 GYMNOS 在时间上调节下游目标，以确保心皮的正确分化。
Lateral organs of plants display asymmetry with abaxial identity being specified by members of the Arabidopsis YABBY gene family. Mutations in CRABS CLAW, the founding family member, display ectopic formation of adaxial carpel tissues only when the functions of other genes, such as GYMNOS or KANADI, are also compromised. Mutations in these genes alone do not result in loss of polar differentiation, and therefore, they act redundantly with CRABS CLAW to establish polarity. As GYMNOS encodes a uniformly expressed homolog of the chromatin-remodeling protein, Mi2, we argue that the unique genetic interactions do not reflect a molecular redundancy. Rather, CRABS CLAW regulates transcription spatially, whereas GYMNOS regulates downstream targets temporally to ensure proper differentiation of the carpels.