New criteria of normal serum lipid levels in Japanese children: The nationwide study
New criteria of normal serum lipid levels in Japanese children: The nationwide study
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DOI：
10.1046/j.1442-200x.2002.01634.x
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发表时间：
2002-12-01
影响因子：
1.4
通讯作者：
Harada, K
中科院分区：
文献类型：
--
作者：
Okada, T;Murata, M;Harada, K
目的：利用日本保健服务协会提供的全国范围内的大型数据进行分析，制定当前日本儿童血脂水平的新标准。方法：以1993-1999年以来接受生活方式相关疾病筛查和护理项目的学童为研究对象，测量血清总胆固醇（TC）、高密度脂蛋白胆固醇（HDLC）和甘油三酯（TG）水平，并计算低密度脂蛋白胆固醇（LDLC）水平。按年龄和性别分析血清脂质水平。对于每种血清脂质，我们提取了年龄和性别特异性组，通过学生 t 检验分析，其平均值与 1999 年的平均值没有统计学差异。结果：TC/LDLC 中，低于 75 个百分位的水平被定义为可接受，从 75 个百分位到第 95 个百分位为临界水平，超过 95 个百分位为高水平。 HDLC 低于第 5 个百分位的水平被定义为低，而 TG 超过第 95 个百分位的水平被定义为高。因此，TC 水平分类如下：可接受的 220 mg/dL。 LDLC 水平也分为：可接受的 140 mg/dL。 TG 的临界值确定为 140 mg/dL，HDLC 的临界值确定为 40 mg/dL。 结论：这一新标准对于儿童合理预防和干预的健康策略具有重要价值。应该强调立即为日本儿童提供一些干预。
Aim : To make new criteria of serum lipid levels in current Japanese children using the large nationwide data provided from Japan Association of Health Service for the analysis.Methods : The subjects were schoolchildren who received screening and care programs for lifestyle related diseases since 1993 1999. Serum total cholesterol (TC), high-density lipoprotein cholesterol (HDLC) and triglyceride (TG) levels were measured, and low-density lipoprotein cholesterol (LDLC) levels were calculated. Serum lipid levels were analyzed by age and sex. For each serum lipid, we extracted age- and sex-specific group which the mean value was not statistically different from that in 1999 by Student's t-test analysis.Results : The level below the 75th percentile was defined to be acceptable, from the 75th to 95th to be borderline and over the 95th to be high in TC/LDLC. The level below the fifth percentile in HDLC was defined to be low and the level over the 95th percentile in TG to be high. Therefore, TC level was categorized as follows: acceptable 220 mg/dL. The LDLC level was also categorized into: acceptable 140 mg/dL. The cut-off value in TG was determined to be 140 mg/dL and in HDLC was 40 mg/dL.Conclusions : This new criteria should prove valuable in health strategies for rational prevention and intervention in children. It should be emphasized to provide some intervention for Japanese children immediately.