Oxidative hemolysis and precipitation of hemoglobin. I. Heinz body anemias as an acceleration of red cell aging.
Oxidative hemolysis and precipitation of hemoglobin. I. Heinz body anemias as an acceleration of red cell aging.
复制标题
氧化溶血和血红蛋白沉淀。
DOI：
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发表时间：
1960
影响因子：
15.9
通讯作者：
D. W. Allen
中科院分区：
文献类型：
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作者：
J. H. Jandl;L. K. Engle;D. W. Allen
近世纪来，某些化学品和药物诱导溶血性贫血的倾向一直是备受关注的主题（1-4）。大多数具有如此活性的物质是含有氨基、硝基或羟基的芳香族化合物，尽管许多无机化合物（例如，羟胺、硝酸盐、亚硝酸盐和氯酸盐）也具有活性（1-4）。这些化合物通常会导致红细胞损伤，而没有证据表明对其他细胞或组织具有特定毒性。溶血过程的特征在于受影响的红细胞中的两个相当明显的特征：1）根据大多数（3）但不是全部（4）的报道，出现血红蛋白的褐色或绿色衍生物，包括高铁血红蛋白; 2）红细胞内形成水不溶性的颗粒，通常称为海因茨小体。关于这些化合物给药后血红蛋白变色的身份和意义存在广泛的争论。大部分的分歧可能归因于这样一个事实，即许多观察是在体内进行的，其中最初由该化合物产生的色素与血红蛋白催化剂的各种产物混合。此外，某些产生的色素（如高铁血红蛋白）是可逆的，而某些其他色素（包括所谓的硫血红蛋白）则不是（3），这一事实无疑导致了相互矛盾的观察结果。在少数几项早期连续观察的研究中，高铁血红蛋白血症虽然短暂，但仍引人注目（5，6）。对苯肼等化合物的研究表明，血红蛋白可能部分转化为蛋氨酸，
The propensity of certain chemicals and drugs to induce hemolytic anemias has been a subject of much interest for almost a century (1-4). The majority of substances so active are aromatic compounds containing amino-, nitro-, or hydroxy groups, although a number of inorganic compounds (e.g., hydroxylamines, nitrates, nitrites and chlorates) are also active (1-4). Such compounds usually cause red cell injury without evidence of specific toxicity to other cells or tissues. The hemolytic process is characterized by two rather distinctive features in the affected red cells: 1) the appearance of l)rownish or greenish derivatives of hemoglobin, including methemoglobin, according to most (3) but not all (4) reports; and 2) the formation within red cells of water-insoluble, stainable granules, generally termed Heinz bodies. There has been extensive debate as to the identity and significance of the hemoglobin discoloration following the adiministration of these compounds. Much of the disagreement may be attributed to the fact that many of the observations have been made in vivo, where pigments initially produced by the compound are mixed with the various products of hemoglobin catabolism. Furthermore, the fact that certain of the pigments produced, such as miiethemoglobin, are reversible, whereas certain others (including so-called sulfhemoglobin) are not (3), has undoubtedly led to conflicting observations. In those few studies where early, sequential observations have been made, methemoglobinemia has been striking albeit transient (5, 6). Studies of compounds such as phenylhydrazine, which are active against red cells in vitro as well as in vivo, have shown that hemoglobin may be changed in part to methemo-