Superparamagnetic Gold Nanoparticles Synthesized on Protein Particle Scaffolds for Cancer Theragnosis
Superparamagnetic Gold Nanoparticles Synthesized on Protein Particle Scaffolds for Cancer Theragnosis
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DOI：
10.1002/adma.201701146
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发表时间：
2017-10-11
影响因子：
29.4
通讯作者：
Lee, Jeewon
中科院分区：
文献类型：
--
作者：
Kwon, Koo Chul;Jo, Eunji;Lee, Jeewon
使用单一多模态药剂的癌症治疗诊断是现代癌症诊断、治疗和管理的下一个支柱，但尚未开发具有体内癌症靶向和治疗诊断功效的临床可行药剂。报道了一种新型的癌症诊断剂，其基于在癌症靶向蛋白颗粒载体上诱导的金磁性。超顺磁性金纳米颗粒簇（称为SPAuNC）在病毒衣壳颗粒上合成，该病毒衣壳颗粒被工程化以呈现靶向肿瘤细胞受体（TCR）的肽配体。观察到SPAuNCs的有效多模态，其使得能够在交变磁场下对活小鼠中的皮下和深部组织肿瘤进行TCR特异性靶向、T-2加权磁共振成像和磁热疗治疗。此外，它解析地阐明了如何SPAuNC的磁性充分诱导之间的局域和离域自旋的Au原子。特别地，SPAuNC显示出优异的生物相容性，而没有体内累积的问题，并且具有作为癌症治疗的临床有效剂的有希望的潜力。
Cancer theragnosis using a single multimodality agent is the next mainstay of modern cancer diagnosis, treatment, and management, but a clinically feasible agent with in vivo cancer targeting and theragnostic efficacy has not yet been developed. A new type of cancer theragnostic agent is reported, based on gold magnetism that is induced on a cancer-targeting protein particle carrier. Superparamagnetic gold-nanoparticle clusters (named SPAuNCs) are synthesized on a viral capsid particle that is engineered to present peptide ligands targeting a tumor cell receptor (TCR). The potent multimodality of the SPAuNCs is observed, which enables TCR-specific targeting, T-2-weighted magnetic resonance imaging, and magnetic hyperthermia therapy of both subcutaneous and deep-tissue tumors in live mice under an alternating magnetic field. Furthermore, it is analytically elucidated how the magnetism of the SPAuNCs is sufficiently induced between localized and delocalized spins of Au atoms. In particular, the SPAuNCs show excellent biocompatibility without the problem of in vivo accumulation and holds promising potential as a clinically effective agent for cancer theragnosis.