Quantification of acetonitrile in exhaled breath and urinary headspace using selected ion flow tube mass spectrometry
Quantification of acetonitrile in exhaled breath and urinary headspace using selected ion flow tube mass spectrometry
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DOI：
10.1016/s1387-3806(03)00212-4
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发表时间：
2003-08-15
影响因子：
1.8
通讯作者：
Smith, D
中科院分区：
文献类型：
--
作者：
Abbott, SM;Elder, JB;Smith, D
使用选择性离子流管质谱法（SIFT-MS）对几名吸烟者和几名非吸烟者呼出的气体和尿液中的乙腈进行了研究。概述了用h30 +离子进行SIFT-MS气相乙腈检测和定量的离子化学过程。除此之外，还进行了实验以确定稀乙腈水溶液的亨利定律分配系数，该系数允许从顶空浓度测定液相尿乙腈浓度。本研究结果表明，在吸烟者的呼吸和尿液顶空中，SIFT-MS很容易检测到乙腈，其水平取决于香烟的消费量，但在非吸烟者的呼吸和尿液顶空中几乎不存在乙腈。利用亨利定律分配系数的测量值，推导出尿相浓度。本研究结果表明，典型的乙腈呼吸浓度在17-124 ppb（平均值69 ppb）范围内，这与以前的研究结果非常一致。尿乙腈浓度在0 ~ 150马克杯/升（平均值57马克杯/升）范围内，与之前测定的血中浓度接近。这些收集到的数据表明乙腈在体液（血液、全身水分和尿液）中是平衡的，并且通过呼出的气和尿液排出。(C) 2003 Elsevier Science B.V.版权所有
A study has been carried out of acetonitrile in exhaled breath and in the headspace of urine from several cigarette smokers and several non-smokers using selected ion flow tube mass spectrometry (SIFT-MS). The ion chemistry involved in the detection and quantification of acetonitrile in the gas phase by SIFT-MS using H3O+ ions is outlined. Further to this, experiments have been carried out to determine the Henry's Law partition coefficients for dilute aqueous solutions of acetonitrile, which allow the determination of liquid phase urinary acetonitrile concentrations from headspace concentrations. The results of this study show that acetonitrile is readily detected by SIFT-MS in the breath and urinary headspace of smokers at levels dependent on the cigarette consumption, but is practically absent from the breath and urine headspace of non-smokers. Exploiting the measured values of the Henry's Law partition coefficients, the urinary phase concentrations have been deduced. The results of this study show that typical breath concentrations of acetonitrile are within the range 17-124 ppb (mean value 69 ppb), which are in close agreement with previous studies. The urinary acetonitrile concentrations are within the range 0-150 mug/L (mean value 57 mug/L), which are close to the concentrations determined previously in blood. These collected data imply that the acetonitrile is equilibrated amongst the body fluids (blood, total body water and urine) and that excretion occurs via both exhaled breath and urine. (C) 2003 Elsevier Science B.V. All rights reserved.