Serum Galectin-3 and Poor Outcomes Among Patients With Acute Ischemic Stroke
Serum Galectin-3 and Poor Outcomes Among Patients With Acute Ischemic Stroke
复制标题
急性缺血性中风患者的血清半乳糖凝集素 3 与不良预后
DOI：
10.1161/strokeaha.117.019084
复制
发表时间：
2018-01-01
期刊：
影响因子：
8.3
通讯作者：
He, Jiang
中科院分区：
文献类型：
--
作者：
Wang, Aili;Zhong, Chongke;He, Jiang
背景和目的：半乳糖凝集素-3水平升高与动脉粥样硬化和心力衰竭患者预后不良有关。然而，目前尚不清楚半乳糖凝集素-3是否对缺血性卒中的不良结局有任何影响。本研究的目的是探讨半乳糖凝集素-3与急性缺血性stroke. Methods患者的不良结局之间的相关性，测定3082例急性缺血性卒中患者血清半乳糖凝集素-3。主要结局是死亡或严重残疾的组合（改良兰金量表评分，>= 3）。结果-与半乳糖凝集素-3的最低四分位数相比，半乳糖凝集素-3的最高四分位数（95%置信区间）为1.55（1.15-2.09），死亡2.10（0.89-4.95），严重残疾1.43（1.05-1.93）。将半乳糖凝集素-3添加到常规危险因素中显著改善了缺血性卒中患者死亡或严重残疾的联合结局预测（净重新分类指数，18.9%; P
Background and Purpose-Elevated galectin-3 has been associated with atherosclerosis and poor outcomes in patients with heart failure. However, it remains unclear whether galectin-3 has any effect on the poor outcomes of ischemic stroke. The aim of the present study was to examine the association between galectin-3 with poor outcomes among patients with acute ischemic stroke.Methods-Serum galectin-3 was measured in 3082 patients with acute ischemic stroke. The primary outcome was a combination of death or major disability (modified Rankin Scale score, >= 3) at 3 months after stroke.Results-Compared with the lowest quartile of galectin-3, multivariate adjusted odds ratios (95% confidence intervals) for the highest quartile of galectin-3 were 1.55 (1.15-2.09) for composite outcome, 2.10 (0.89-4.95) for death, and 1.43 (1.05-1.93) for major disability. The addition of galectin-3 to the conventional risk factors significantly improved prediction of the combined outcome of death or major disability in patients with ischemic stroke (net reclassification index, 18.9%; P