Volume-Related Weight Gain and Subsequent Mortality in Acute Renal Failure Patients Treated With Continuous Renal Replacement Therapy
Volume-Related Weight Gain and Subsequent Mortality in Acute Renal Failure Patients Treated With Continuous Renal Replacement Therapy
复制标题
DOI：
10.1097/mat.0b013e3181de35e4
复制
发表时间：
2010-07-01
期刊：
影响因子：
4.2
通讯作者：
Juncos, Luis A.
中科院分区：
文献类型：
--
作者：
Fulop, Tibor;Pathak, Minesh B.;Juncos, Luis A.
液体超负荷是急性肾损伤（阿基）危重患者的常见症状。为了评估液体超负荷对接受连续性肾脏替代治疗（CRRT）的阿基患者死亡率的影响，我们对81例开始CRRT治疗的阿基危重患者进行了登记，收集了18个月的数据，使用体积相关体重增加（VRWG）>= 10%和>= 20%的体重和少尿进行了横断面分析。（= 10%）和3.22（95%CI：1.23-8.45）少尿。VRWG >= 20%的死亡率OR为3.98（95% CI：1.01-15.75; p = 0.049）。在包括脓毒症和Apache II评分的多变量模型中，VRWG ≥ 10%（OR 2.71，p = 0.040）和少尿（OR 3.04，p = 0.032）与死亡率保持统计学显著相关性。总之，液体超负荷是接受CRRT治疗的危重阿基患者生存的重要预后因素。需要进一步研究，以找出机制并制定适当的干预措施。ASAIO Journal 2010; 56：333-337.
Fluid overload is a frequent finding in critically ill patients suffering from acute kidney injury (AKI). To assess the impact of fluid overload on the mortality of AKI patients treated with continuous renal replacement therapy (CRRT), we used a registry of 81 critically ill patients with AKI initiated on CRRT assembled over an 18-month period to conduct a cross-sectional analysis using volume-related weight gain (VRWG) of >= 10% and >= 20% of body weight and oliguria (= 10% and to 3.22 (95% CI: 1.23-8.45) by oliguria. VRWG >= 20% had OR of 3.98 (95% CI: 1.01-15.75; p = 0.049) for mortality. Both VRWG >= 10% (OR 2.71, p = 0.040) and oliguria (OR 3.04, p = 0.032) maintained their statistically significant association with mortality in multivariate models that included sepsis and Apache II score. In conclusion, fluid overload is an important prognostic factor for survival in critically ill AKI patients treated with CRRT. Further studies are needed to elicit mechanisms and develop appropriate interventions. ASAIO Journal 2010; 56:333-337.