Bright light therapy for depression: a review of its effects on chronobiology and the autonomic nervous system.
Bright light therapy for depression: a review of its effects on chronobiology and the autonomic nervous system.
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DOI：
10.3109/07420528.2013.833935
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发表时间：
2014-04
影响因子：
2.8
通讯作者：
Ciraulo DA
中科院分区：
文献类型：
--
作者：
Oldham MA;Ciraulo DA
强光疗法(BLT)被认为是季节性情感障碍(SAD)的一线治疗方法之一，但越来越多的文献支持将其用于其他神经精神疾病，包括非季节性抑郁症。尽管有证据表明BLT的抗抑郁效果，但国际上对BLT的临床应用仍存在很大差异。在这篇文章中，我们探讨了BLT的自主神经作用，并认为这种作用可能在其抗抑郁和时辰治疗特性中发挥作用。在简要介绍了BLT的临床应用后，我们回顾了BLT对抑郁症的时间生物学效应，以及对抑郁症和非抑郁症患者自主神经系统的影响，重点是非季节性抑郁症。这种通过BLT调节自主神经的理论可以用来整合最近以减轻变态负荷为中心的工作、多迷走神经理论、神经内脏整合模型以及关于谷氨酸和伽马羟丁酸(GABA)作用的新证据。
Bright light therapy (BLT) is considered among the first-line treatments for seasonal affective disorder (SAD), yet a growing body of literature supports its use in other neuropsychiatric conditions including non-seasonal depression. Despite evidence of its antidepressant efficacy, clinical use of BLT remains highly variable internationally. In this article, we explore the autonomic effects of BLT and suggest that such effects may play a role in its antidepressant and chronotherapeutic properties. After providing a brief introduction on the clinical application of BLT, we review the chronobiological effects of BLT on depression and on the autonomic nervous system in depressed and non-depressed individuals with an emphasis on non-seasonal depression. Such a theory of autonomic modulation via BLT could serve to integrate aspects of recent work centered on alleviating allostatic load, the polyvagal theory, the neurovisceral integration model and emerging evidence on the roles of glutamate and gamma-hydroxybutyric acid (GABA).