Multifunctional proteins: examples of gene sharing
Multifunctional proteins: examples of gene sharing
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DOI：
10.1080/07853890310004101
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发表时间：
2003-01-01
影响因子：
4.4
通讯作者：
Jeffery, CJ
中科院分区：
文献类型：
--
作者：
Jeffery, CJ
单个蛋白质可以“兼职”或执行多种显然不相关的功能，这增加了解释人类基因组序列和注释蛋白质序列数据库的难度。这篇综述总结了在癌症和其他疾病中重要的细胞活动和生化途径中兼职蛋白质的例子。这些蛋白质包括多种功能组合和功能之间切换的机制。兼职蛋白质可能对生物体有益，例如通过协调细胞活动。然而，兼职蛋白质可能会使疾病分子机制的确定和合理药物设计的过程变得更加困难。
Adding to the difficulty of interpreting the human genome sequence and annotating protein sequence databases is the observation that a single protein can 'moonlight' or perform multiple, apparently unrelated, functions. This review summarizes examples of moonlighting proteins in cellular activities and biochemical pathways important in cancer and other diseases. The proteins include a variety of combinations of functions and mechanisms to switch between functions. Moonlighting proteins can be beneficial to the organism, such as by coordinating cellular activities. However, moonlighting proteins can potentially make more difficult the determination of the molecular mechanisms of disease and the process of rational drug design.