Health-related quality of life in patients with idiopathic pulmonary fibrosis. What is the main contributing factor?
Health-related quality of life in patients with idiopathic pulmonary fibrosis. What is the main contributing factor?
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DOI：
10.1016/j.rmed.2004.09.005
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发表时间：
2005-04-01
影响因子：
4.3
通讯作者：
Nishimura, K
中科院分区：
文献类型：
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作者：
Nishiyama, O;Taniguchi, H;Nishimura, K
特发性肺纤维化（IPF）患者的预后通常被认为较差。随着病情的发展，患者的活动总是受到严重限制。因此，评估IPF患者的健康相关生活质量（HRQoL）被认为是重要的。我们对41例连续的IPF患者应用圣乔治呼吸问卷（SGRQ），检查各种生理变量，以确定与HRQoL相关的因素：总肺容量、转移因子、静息时动脉血氧分压、运动试验期间的最低血氧饱和度、基线呼吸困难指数（BDI）评分与SGRQ总分显著相关。在每个组分中观察到类似的趋势。相反，峰值摄氧量（已知为决定慢性阻塞性肺疾病（COPD）HRQoL的重要因素之一）与任何SGRQ评分均不相关。多元逐步回归分析结果显示，BDI评分是影响SGRQ总分的唯一因素，呼吸困难是影响IPF患者HRQoL的最重要因素，其他与IPF患者HRQoL相关的变量类型与COPD患者不同。(c)2004爱思唯尔有限公司保留所有权利。
The prognosis of patients with idiopathic pulmonary fibrosis (IPF) is generally considered to be poor. As the disease progresses, patients invariably become severely limited in their activities. Therefore, evaluating the health-related quality of life (HRQoL) in IPF patients is considered to be important. However, there have been few studies of this kind to date.We applied the St. George's Respiratory Questionnaire (SGRQ) to 41 consecutive IPF patients and examined various physiological variables to identify factors that were correlated with the HRQoL.Total lung capacity, transfer factor, arterial partial pressure of oxygen at rest, the lowest oxygen saturation during exercise test, and the baseline dyspnoea index (BDI) score were significantly correlated with the total SGRQ score. A similar tendency was observed in each component. Conversely, peak oxygen uptake, known as one of the important factors that determines HRQoL in chronic obstructive pulmonary disease (COPD), did not correlate with any SGRQ scores. In stepwise multiple regression analysis, the BDI score was selected as the only factor significantly contributing to the total SGRQ score.Dyspnoea was the most important factor determining HRQoL in IPF The types of other variables that correlated with the HRQoL in IPF patients were different from those in COPD. (c) 2004 Elsevier Ltd. All rights reserved.