Two Acute Liver Injuries in a Patient With Malnutrition.
Two Acute Liver Injuries in a Patient With Malnutrition.
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DOI：
10.14740/jmc3713
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发表时间：
2021-08
期刊：
影响因子：
--
通讯作者：
Chen PH
中科院分区：
文献类型：
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作者：
Su A;Choe M;Birkness JE;Limketkai B;Chen PH
慢性饥饿和重新进食与肝损伤(LI)有关。我们报告一位神经性厌食症患者，他表现出两种与营养不良相关的LI现象。门冬氨酸氨基转移酶和丙氨酸氨基转移酶分别在154U/L和136U/L时升高，随着营养的引入迅速升高，峰值分别为750U/L和638U/L。饥饿相关LI的机制包括脂质的降解和分泌受损，以及饥饿诱导的自噬。再次进食时的LI可能与葡萄糖供应的迅速增加有关。这些现象对于正在接受重新喂养的慢性饥饿患者来说是至关重要的。
Chronic starvation and refeeding have been associated with liver injury (LI). We present a patient with anorexia nervosa who exhibited both phenomena of malnutrition-related LI. At presentation, aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were elevated at 154 and 136 U/L, respectively, and rose rapidly to peaks of 750 and 638 U/L, respectively, as nutrition was introduced. Mechanisms of starvation-related LI include impaired degradation and secretion of lipids, as well as starvation-induced autophagy. LI during refeeding may be related to rapid increase in glucose availability. These phenomena are crucial to consider in patients with chronic starvation undergoing refeeding.