Generation of kinin-like agents by chondroitin sulfate, heparin, chitin sulfate, and human articular cartilage: possible pathophysiologic implications.
Generation of kinin-like agents by chondroitin sulfate, heparin, chitin sulfate, and human articular cartilage: possible pathophysiologic implications.
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硫酸软骨素、肝素、硫酸几丁质和人关节软骨产生激肽样物质：可能的病理生理学影响。
DOI：
10.5555/uri:pii:0022214370902179
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发表时间：
1970
期刊：
影响因子：
--
通讯作者：
Tage Astrup
中科院分区：
文献类型：
--
作者：
Roland W. Moskowitz;H. J. Schwartz;Beno Michel;O. Ratnoff;Tage Astrup
Abstract Kinin-like activity evolved in mixtures of normal human platelet-deficient plasma containing human articular cartilage, chondroitin sulfate, heparin, or chitin sulfate. No such activity evolved when these agents were incubated with Hageman factor-deficient platelet-deficient plasma. The kinin-like agent was eluted from a Sephadex G-25 column at a peak near that of synthetic bradykinin; it was inactivated by chymotrypsin (100 μg per milliliter), but not by trypsin (20 μg per milliliter). Generation of kinin-like substances induced by components of articular cartilage may involve the participation of Hageman factor and may contribute to secondary inflammatory reactions in joints.
