Mathematical model for optimal use of sulfadoxine-pyrimethamine as a temporary malaria vaccine.
Mathematical model for optimal use of sulfadoxine-pyrimethamine as a temporary malaria vaccine.
复制标题
磺胺多辛-乙胺嘧啶作为临时疟疾疫苗的最佳使用的数学模型。
DOI：
10.1007/s11538-009-9476-9
复制
发表时间：
2010
影响因子：
3.5
通讯作者：
Yakubu,Abdul-Aziz
中科院分区：
文献类型：
--
作者：
Dembele,Bassidy;Friedman,Avner;Yakubu,Abdul-Aziz
In this paper, we introduce a deterministic malaria model for determining the drug administration protocol that leads to the smallest first malaria episodes during the wet season. To explore the effects of administering the malaria drug on different days during the wet season while minimizing the potential harmful effects of drug overdose, we define 40 drug administration protocols. Our results fit well with the clinical studies of Coulibaly et al. at a site in Mali. In addition, we provide protocols that lead to smaller number of first malaria episodes during the wet season than the protocol of Coulibaly et al.
