Diphasic Worsening of Freezing of Gait in Parkinson's Disease.
Diphasic Worsening of Freezing of Gait in Parkinson's Disease.
复制标题
帕金森病冻结步态的双相恶化。
DOI：
10.1002/mdc3.12918
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发表时间：
2020
影响因子：
4
通讯作者：
Factor,StewartA
中科院分区：
文献类型：
--
作者：
PerezParra,Sahyli;McKay,JLucas;Factor,StewartA
背景步态冻结（FOG）与左旋多巴反应的关系是复杂的。有些患者有反应，有些没有反应，有些患者左旋多巴会引起FOG。我们介绍了2例表现出双相恶化FOG后左旋多巴dosing.CasesTwo PD患者FOG进行了检查，在实际定义的offstate，从offtoon（15和22分钟后给药），并在fullonstate（45和60分钟后给药）的过渡。使用运动障碍协会统一帕金森病评定量表第III部分第11项：步态冻结来测量FOG。两例患者在转换期间FOG恶化，随后在开启状态期间改善。例1测定了血清左旋多巴水平。视频提供。ConclusionsTo我们所知，这种双相模式的恶化FOG以前没有报道。这种现象的原因尚不清楚，但可能与亚阈值水平的左旋多巴的抑制作用有关。
BackgroundThe relationship between freezing of gait (FOG) and levodopa response is complex. Some patients respond, some have no response and in some patients levodopa causes FOG. We present 2 cases demonstrating a diphasic worsening of FOG after levodopa dosing.CasesTwo PD patients with FOG were examined during the practically definedoffstate, the transition fromofftoon(15 and 22 minutes postdose), and in the fullonstate (45 and 60 minutes postdose). FOG was measured using Movement Disorder Society–Unified Parkinson's Disease Rating Scale part III, item 11: freezing of gait. Both patients experienced worsening of FOG during the transition followed by improvement during theonstate. Case 1 had serum levodopa levels measured. Videos are provided.ConclusionsTo our knowledge, this diphasic pattern of worsening of FOG has not been previously reported. The cause of this phenomenon is unknown but may relate to an inhibitory action of subthreshold levels of levodopa.