ENHANCED OTOTOXICITY OF GENTAMICIN AND SALICYLATE CAUSED BY MG DEFICIENCY AND ZN DEFICIENCY
ENHANCED OTOTOXICITY OF GENTAMICIN AND SALICYLATE CAUSED BY MG DEFICIENCY AND ZN DEFICIENCY
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DOI：
10.1007/bf02795332
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发表时间：
1988-06-01
影响因子：
3.9
通讯作者：
ISING, H
中科院分区：
文献类型：
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作者：
GUNTHER, T;REBENTISCH, E;ISING, H
在大鼠中，镁缺乏导致了中度听力损失，通过10和20 kHz的诱发电位测量，在重新喂食正常饮食后得到修复。应用700 mg/kg水杨酸或注射5×100 mg/kg庆大霉素也可引起正常喂养大鼠的可逆性听力损失。用水杨酸治疗锌缺乏的大鼠比正常喂养的水杨酸治疗的大鼠听力损失更严重，尽管是可逆的。用庆大霉素治疗缺镁大鼠后，25只大鼠中有9只发生了几乎完全且不可逆的听力损失。
In rats, Mg deficiency caused a moderate hearing loss, measured by means of evoked potentials at 10 and 20 kHz, which was repaired after refeeding a normal diet. Application of 700 mg/kg salicylic acid or injection of 5 x 100 mg/kg gentamicin also caused a reversible hearing loss in normally fed rats. Treatment of Zn-deficient rats with salicylic acid produced a stronger although reversible hearing loss than in normally fed salicylate-treated rats. Treatment of Mg-deficient rats with gentamicin induced a strong hearing loss that was nearly complete and irreversible in 9 of 25 rats.