Abnormal functional connectivity density in patients with major depressive disorder with comorbid insomnia
Abnormal functional connectivity density in patients with major depressive disorder with comorbid insomnia
复制标题
重度抑郁障碍伴失眠患者的功能连接密度异常
DOI：
10.1016/j.jad.2020.01.088
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发表时间：
2020-04-01
影响因子：
6.6
通讯作者：
Xi, Chunhua
中科院分区：
文献类型：
--
作者：
Gong, Liang;Xu, Ronghua;Xi, Chunhua
背景：抑郁症是重性抑郁障碍（MDD）患者常见的合并症。然而，MDD伴高水平失眠（MDD-HI）和低水平失眠（MDD-LI）的脑功能改变尚不清楚。在这里，我们调查了失眠症与全球功能连接密度（gFCD）在MDD患者。方法：共招募了148名参与者，并进行了静息态功能磁共振成像。结果：两组MDD患者双侧海马旁回/海马回（PHG/HIP）的gFCD均高于健康对照组，MDD-LI组高于MDD-HI组，左侧梭状回的gFCD低于健康对照组。MDD-HI组左侧颞下回（ITG）的gFCD高于MDD-LI组和HC组。左ITG和后PHG/HIP的gFCD与失眠相关，而左前PHG/HIP的gFCD与MDD组的非失眠抑郁症状相关。局限性：横断面设计和使用简短/主观的失眠assessments.Conclusions：本研究表明，MDD的异常脑功能与不同的失眠症状。重要的是，在抑郁症患者中，海马体的后部和前部可能在失眠的存在或不存在中发挥不同的作用。
Background: Insomnia is a common comorbidity symptom in patients with major depressive disorder (MDD). However, the brain functional alteration in MDD with higher level insomnia (MDD-HI) and lower level insomnia (MDD-LI) remains unclear. Here, we investigated the association of insomnia with global functional connectivity density (gFCD) in patients with MDD.Methods: A total of 148 participants were recruited and underwent resting-state functional magnetic resonance imaging. A voxel-wise analysis of covariance was employed to explore group differences in gFCD among the MDD-HI, MDD-LI and healthy control (HC) groups.Results: The gFCD in the bilateral parahippocampal/hippocampal gyri (PHG/HIP) was higher in the two MDD than in the HC group, and it was higher in the MDD-LI than in the MDD-HI group; the gFCD in the left fusiform area was lower in the MDD than in the HC group. The gFCD in the left inferior temporal gyrus (ITG) was higher in the MDD-HI than in the MDD-LI and HC groups. The gFCD in the left ITG and posterior PHG/HIP was associated with insomnia, while the gFCD in the left anterior PHG/HIP was correlated with non-insomnia depressive symptoms in the MDD group.Limitations: The cross-sectional design and the use of brief/subjective insomnia assessments.Conclusions: The present study showed that the abnormal brain features of MDD with different insomnia symptom. Importantly, the posterior and anterior parts of the hippocampus may play different roles in the presence or absence of insomnia in patients with MDD.