Escalated Aggression in Animal Models: Shedding New Light on Mesocorticolimbic Circuits.
Escalated Aggression in Animal Models: Shedding New Light on Mesocorticolimbic Circuits.
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DOI：
10.1016/j.cobeha.2015.02.007
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发表时间：
2015-06-01
影响因子：
5
通讯作者：
de Almeida RM
中科院分区：
文献类型：
--
作者：
Miczek KA;Takahashi A;Gobrogge KL;Hwa LS;de Almeida RM
最近的发展承诺显着推进研究不足的行为和神经生物学的攻击：（1）动物模型，捕捉人类暴力和无情的基本特征已经开发出来。这些模型的范围从选择性繁殖用于短期攻击的小鼠、一夫一妻制的草原田鼠和糖皮质激素受损的大鼠到啮齿动物和非人类灵长类动物，这些动物在饮酒或戒酒后会升级其攻击性。(2)光遗传学刺激和基于病毒载体的方法已经开始在几种啮齿动物模型中识别重叠和独特的神经微电路和细胞内分子，用于适应性与过度，适应不良的攻击行为。从下丘脑和中脑神经元到内侧前额叶皮质的投射中包含了对攻击升级至关重要的微电路。
Recent developments promise to significantly advance the understudied behavioral and neurobiology of aggression: (1) Animal models that capture essential features of human violence and callousness have been developed. These models range from mice that have been selectively bred for short attack latencies, monogamous prairie voles, and glucocorticoid-compromised rats to rodents and non-human primates that escalate their aggression after consuming or when withdrawing from alcohol. (2) Optogenetic stimulation and viral vector-based approaches have begun to identify overlapping and distinctive neural microcircuits and intracellular molecules for adaptive vs. excessive, maladaptive aggressive behavior in several rodent models. Projections from hypothalamic and mesencephalic neurons to the medial prefrontal cortex contain microcircuits that appear pivotal for the escalation of aggression.