MAKE IT OR BREAK IT - THE ROLE OF UBIQUITIN-DEPENDENT PROTEOLYSIS IN CELLULAR-REGULATION
MAKE IT OR BREAK IT - THE ROLE OF UBIQUITIN-DEPENDENT PROTEOLYSIS IN CELLULAR-REGULATION
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DOI：
10.1016/s0962-8924(00)89102-3
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发表时间：
1995-11-01
影响因子：
19
通讯作者：
DESHAIES, RJ
中科院分区：
文献类型：
--
作者：
DESHAIES, RJ
细胞内蛋白质浓度的有效调节需要蛋白质的快速降解。直到最近，人们还普遍认为细胞内蛋白水解主要局限于受损或异常蛋白的周转率。然而，最近，蛋白质降解在细胞调节中的作用已成为焦点，泛素/蛋白酶体依赖的蛋白质水解已被证明在胚胎发育、转录和细胞周期等多种过程中发挥关键作用。
Effective regulation of the concentration of a protein in the cell requires rapid protein degradation. Until recently, it was widely believed that intracellular proteolysis was largely confined to the turnover of damaged, or of otherwise abnormal, proteins. Recently, however, the role of protein degradation in cellular regulation has gained centre stage, and ubiquitin/proteasome-dependent proteolysis has been shown to play a key role in processes as diverse as embryonic development, transcription and the cell cycle.