Levels of 25 cytokines in the first seven days of life in newborn infants.
Levels of 25 cytokines in the first seven days of life in newborn infants.
复制标题
DOI：
10.1186/1756-0500-6-547
复制
发表时间：
2013-12-20
影响因子：
1.8
通讯作者：
Sauer PJ
中科院分区：
文献类型：
--
作者：
Lusyati S;Hulzebos CV;Zandvoort J;Sauer PJ
细胞因子分析的新方法可以同时测量 50 µL 血清或血浆中的 25 种细胞因子。缺乏大多数这些细胞因子在未感染新生儿中的值的数据。我们分析了未感染的早产儿和足月儿出生后第一周的 25 种细胞因子水平，并将其与胎龄联系起来。在出生后第一周，任何细胞因子均未发现随时间变化的趋势，但 IL-1Ra 和 IL-6 除外，在前四个小时内发现较高值。与 ≥ 36 周的婴儿相比，30-32 周后出生的婴儿在 24 至 72 小时之间的 IL-1Ra、IL-2、IL-8、IL-12、IL-13、IL-15、IL-17、IFNγ、MIP-1a、MCP-1、TNFα 水平较低； 30-32 周和 33-36 周的早产儿的 IL-6、IL-10、IP-10 水平较低。 IL-1b、IL-2r、IL-4、IL-5、IL-7、IFNa、MIP-1b、GM-CSF、Eotaxin 和 RANTES 的任何水平在各组之间均未发现差异。未感染婴儿出生后第一周，25 种白介素水平保持稳定。与 36 周以上出生的婴儿相比，30-32 周后出生的婴儿显示出较低的 14 种细胞因子水平。这表明这些婴儿中 Th-1 细胞、单核细胞和树突状细胞的刺激或激活较低。
Novel methods for cytokine analysis allow for the simultaneous measurement of 25 cytokines in 50 μL serum or plasma. Data on values of most of these cytokines in non-infected newborn infants are lacking. We analyzed levels of 25 cytokines in the first week of life in non-infected preterm and term infants and related them to gestational age. During the first week after birth, no trend over time was found in any of the cytokines, except for IL-1Ra and IL-6 where higher values were found in the first four hours. Between 24 and 72 hrs levels of IL-1Ra, IL-2, IL-8, IL-12, IL-13, IL-15, IL-17, IFNγ, MIP-1a, MCP-1, TNFα were lower in infants born after 30-32 wks compared to infants ≥36 wks; levels of IL-6, IL-10, IP-10 were lower in preterm infants of both 30–32 and 33–36 weeks. No difference between groups for any of the levels was found for IL-1b, IL-2r, IL-4, IL-5, IL-7, IFNa, MIP-1b, GM-CSF, Eotaxin and RANTES. Levels of 25 interleukines are stable in the first week of life in non-infected infants. Infants born after 30-32 wks showed lower levels of fourteen cytokines compared to infants born after more then 36 wks. This indicates a lower stimulation or activation of Th-1 cells, monocytes and dendritic cells in these infants.