MT-MMPs play pivotal roles in cancer dissemination
MT-MMPs play pivotal roles in cancer dissemination
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DOI：
10.1023/a:1015527220537
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发表时间：
2004
影响因子：
4
通讯作者：
I. Yana;M. Seiki
中科院分区：
文献类型：
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作者：
I. Yana;M. Seiki
基质金属蛋白酶（Matrix metalloproteinases，MMPs）是一种锌结合内肽酶家族，在肿瘤的增殖和转移中起重要作用，并可能与其他疾病相关。特别是，膜型MMPs（MT-MMPs）对于癌细胞侵袭至关重要。在这份报告中，我们总结了目前的观点MT-MMPs在癌症传播中的作用。肿瘤表面周围细胞外基质（ECM）的受调节和受限制的降解是细胞突起和侵袭的触发事件。这被认为主要是由MT-MMP组织的，因为在病灶细胞表面的细胞粘附分子、ECM和蛋白水解之间的平衡的转变可能导致特别适合于癌细胞进展和侵入ECM的条件。为了解决肿瘤侵袭和迁移的生理机制，应进一步检查每种细胞类型的肿瘤细胞表面表达的MT-MMPs周围的分子环境，这可能因此提供一种新的临床工具来调节癌症的行为。
Matrix metalloproteinases (MMPs), a family of zinc-binding endopeptidases, play important roles in cancer proliferation and dissemination, and may be further associated with other diseases. In particular, membrane-type MMPs (MT-MMPs) are crucial for cancer cell invasion. In this report, we summarize the current views on the role of MT-MMPs in cancer dissemination. The regulated and restricted degradation of the extracellular matrix (ECM) surrounding the tumor surface is a trigger event for cell protrusion and invasion. This is thought to be primarily organized by MT-MMPs, since a shift in balance between cell adhesion molecules, ECM and proteolysis at the focal cell surface may result in conditions especially suitable for cancer cells to progress and invade the ECM. To resolve the physiological mechanisms of cancer invasion and migration, molecular milieu surrounding the MT-MMPs expressed on tumor cell surfaces should be further examined for each cell type, which may consequently provide a novel clinical tool to regulate cancer behavior.