The emergence of ribozymes synthesizing membrane components in RNA-based protocells
The emergence of ribozymes synthesizing membrane components in RNA-based protocells
复制标题
在基于 RNA 的原始细胞中合成膜成分的核酶的出现
DOI：
10.1016/j.biosystems.2009.11.003
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发表时间：
2010-03-01
期刊：
影响因子：
1.6
通讯作者：
Hu, Jiming
中科院分区：
文献类型：
--
作者：
Ma, Wentao;Yu, Chunwu;Hu, Jiming
生命起源的一个重要问题是细胞自我复制的出现。在“RNA世界”的背景下，一个关键的问题是基于RNA的原细胞如何能够产生自己的膜。在这里，我们在计算机模拟的帮助下表明，对于这些原细胞来说，对于合成膜成分的核酶的出现，将会“立即”产生选择压力。核酶可以促进细胞空间的扩大，有利于RNA前体的进入(通过渗透)，从而有利于内部RNA的复制，包括自身的复制。含有核酶的原生细胞通过生长和分裂获得优势并在系统中扩散，同时核酶也会在系统中扩散。目前的工作是鼓舞人心的，因为它表明从分子自我复制到细胞自我复制的转变可能发生在生命起源的自然(也是必然的)，导致了达尔文进化在细胞水平的出现。(C)2009爱思唯尔爱尔兰有限公司。保留所有权利。
A significant problem of the origin of life is the emergence of cellular self-replication. In the context of the "RNA world", a crucial concern is how the RNA-based protocells could achieve the ability to produce their own membrane. Here we show, with the aid of a computer simulation, that for these protocells, there would be "immediately" a selection pressure for the emergence of a ribozyme synthesizing membrane components. The ribozyme would promote the enlargement of cellular space and favor the incoming (by permeation) of RNA's precursors, thus benefit the replication of inner RNA, including itself. Via growth and division, protocells containing the ribozyme would achieve superiority and spread in the system, and meanwhile the ribozyme would spread in the system. The present work is inspiring because it suggests that the transition from molecular self-replication to cellular self-replication might have occurred naturally (and necessarily) in the origin of life, leading to the emergence of Darwinian evolution at the cellular level. (C) 2009 Elsevier Ireland Ltd. All rights reserved.